Memorial Sloan Kettering Cancer Center
New York, 10065, United States
Completed
NCT Number: NCT00579618
Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging
The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.
Completed
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Notify MeKey information
Conditions
Age range
60 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
This is a protocol to obtain saliva or blood samples from non-cancer affected volunteers aged 60 years or older, without a history of cancer other than non-melanoma skin cancer. These samples will be used in a genomic approach to elucidate novel pathways of cancer predisposition.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation.
- Subjects will self-identify religion and country of origin of grandparents.
- Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.
Exclusion criteria
- Subjects with mental impairment will be excluded from this study.
Treatment and study plan
Saliva or Blood samples
OtherExtracting sample of saliva or blood only once.
Primary outcomes
-
obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly.
Time frame: conclusion of the study
Secondary outcomes
-
samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2.
Time frame: conclusion of the study
Sponsors and collaborators
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Collaborators
- Beth Abraham
- Gurwin Jewish Nursing & Rehabilitation Center
- Hebrew Home at Riverdale
- JASA at Temple Emanuel of Parkchester Senior Center
- Jewish Home & Hospital Lifecare System
- Lenox Hill Neighborhood House
- Margaret Tietz Nursing and Rehabilitation Center
- Metropolitan Jewish Health System
- Northern Services Group
- Parker Jewish Institute
- Susan G. Komen Breast Cancer Foundation
- Van Cortlandt Village Senior Center
Registry information
Important dates
- Study start
- 2006
- Primary completion
- 2017
- Study completion
- 2017
- First posted
- Dec 24, 2007
- Registry last updated
- Jul 31, 2017
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.