Ascending Single Dose Study of Rhu-pGelsolin in Patients With Decreased Gelsolin Levels

This is a randomized, double-blind, placebo-controlled, ascending single dose of rhu-pGelsolin infusion study. Thirteen subjects (10 active and 3 placebo) will be dosed at 3 mg/kg and 5 subjects (3 active and 2 placebo) will be dosed at 6 mg/kg. In addition, twenty-two subjects (18 active and 4 placebo) will be dosed at 6 mg/kg per day for 3 days. The Data Safety Monitoring Committee (DSMC) and Steering Committee will review the preceding dose safety data, and agree the tolerability prior to the enrolment for next higher dose. Blood samples will be collected during 1 hour infusion through 72 hours post dose for PK assessment after each dose.

Inclusion criteria

• >18 years of age
• Documented gelsolin level <100 mg/mL
• Admission to ICU
• Women of child-bearing age have a negative pregnancy test
• Multiple Organ Failure score < 4
• Catheter present through which blood samples can be taken
• Written Informed Consent obtained

Exclusion criteria

• Participation in other investigational treatment protocols
• Patients <18 years of age
• Patients who have a modified Multiple Organ Failure score of >=4
• Patient, who in the opinion of the Principal Investigator, are unlikely to be in the ICU for >48 hours