AS-OCT Guided Treatment of Diffuse CSCC

A prospective study was performed on 8 eyes of 8 patients who underwent amniotic membrane graft after diffuse conjunctival squamous cell neoplasia excision followed by topical mitomycin C 0.04% eye drop between March 2014 and January 2018.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Conjunctival Neoplasms Conjunctival Diseases Eye Diseases Eye Neoplasms Neoplasms Neoplasms by Site

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Surgical excision of the conjunctival tumour . A superficial corneal scraping was performed for corneal lesion then double freeze-thaw cryotherapy was applied to limbal edge and conjunctival margins.The amniotic membrane graft was secure and attached to the sclera and conjunctiva using ﬁbrin glue.Topical mitomycin C 0.04%eye drop was prescribed 4 times daily per treatment cycle (1 cycle=1 week on 1 week off).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

diffuse Ocular Surface Squamous Neoplasia

Exclusion criteria

localized OSSN (less than ﬁve clock hours in limbal extent)

Treatment and study plan

Treatment of diffuse ocular surface squamous neoplasia

Procedure

Excision of the conjunctival tumour was done.Amniotic membrane was secured into conjunctival defects. Postoperative topical MMC 0.04% was given. Response to treatment was monitored clinically and by AS-OCT.

Primary outcomes

The recurrence rate of lesion

Time frame: 2 years

Any recurrence which is detected clinically or/and by AS-OCT

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Treatment of Diffuse Conjunctival Squamous Cell Carcinoma (CSCC) With Excision, Amniotic Membrane Graft Using Fibrin Glue and Topical Mitomycin C (MMC)

Important dates

Study start: 2014
Primary completion: 2018
Study completion: 2018
First posted: May 4, 2018
Registry last updated: Jan 2, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed