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Completed

NCT Number: NCT05056948

Artificial Intelligence Designed Single Tooth Dental Prostheses

Tooth loss is common and as consequence deteriorate patient's health and quality-of-life. Dental prostheses aim to restore patients' appearance and functions by replacement of missing teeth. The occlusal morphology and 3D position of the healthy natural teeth should be adopted by the dental prostheses (biomimetic). Despite computer-assisted design (CAD) software are available for designing dental prostheses, considerable clinical time are still required to fit the dental prostheses into patients' occlusion (teeth-to-teeth relationship). Teeth of an individual subjects are genetically controlled and exposed to mostly identical oral environment, therefore the occlusal morphology and 3D position of teeth are inter-related. It is hypothesized that artificial intelligence (AI) can automated designing the single-tooth dental prostheses from the features of remaining dentition.

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Key information

Conditions

Dental Prosthesis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Prince Philip Dental Hospital

Sai Ying Pun, Hong Kong

About this study

Objectives:

  • To compare four deep-learning methods/algorithms in interpreting and learning of the features of 3D models;
  • To compare the AI system with maxillary tooth model alone to maxillary and mandibular (antagonist) models;
  • To compare the occlusal morphology and 3D position of the single-tooth dental prostheses designed by trained AI and by dental technicians.

Methods:

First, investigators will collect 200 maxillary dentate teeth models as training models. AI will learn the relationship between individual teeth and rest of the dentition using the 3D Generative Adversarial Network (GAN) by following deep-learning methods/algorithms:

Group 1) Voxel-based; Group 2) View-based; Group 3) Point-based; and Group 4) Fusion methods. Investigators will collect another 100 maxillary models that serve as validation models. Investigators will remove a tooth (act as control) in each model. Then investigators will evaluate these deep learning algorithms in predicting the occlusal morphology and 3D position of single-missing tooth.

Second, investigators will evaluate the need of antagonist model in predicting the occlusal morphology and 3D position of single-missing tooth in 100 validation models:

Group i) maxillary model only and Group ii) with antagonist model using the tested deep-learning algorithm in objective (1).

Third, investigators will analyze the geometric morphometric and 3D position of dental prostheses designed by:

Group a) the trained AI system; Group b) dental technicians on the physical models; and Group c) dental technicians using CAD software. Investigators will compare these teeth to the corresponding natural teeth (control) in 100 validation models.

Furthermore, investigators will analyze the time required for tooth design in these groups as secondary outcome.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects with sufficient dentition present for the determination of the upper occlusal plane
  • Subjects with more than 12 occluding pairs and stable intercuspal position
  • Subjects with teeth restorations that did not grossly alter its morphology
  • Subjects who did not undergo orthodontic treatment and/or did not have teeth that rotated more than 45 degrees and/or displaced more than 1.5 mm
  • Subjects who are of Cantonese descent.

Exclusion criteria

  • Subjects with periodontal disease whereby there is pathological tooth migration and alteration of occlusal plane.
  • Subjects who are under the age of 18 and unable to give consent.
  • Subjects with extensive teeth restorations that affect the morphology.

Treatment and study plan

artificial intelligence (AI) computer assisted design (CAD)

Other

Maxillary right first molar will be removed in the computer and will be designed by artificial intelligence system

Primary outcomes

  1. 3D position of tooth

    Time frame: Outcome will be measured when 25% of training models were studied by AI, up to 6 months

    The center of a tooth automatically determined by computer

  2. 3D position of tooth

    Time frame: Outcome will be measured when 50% of training models were studied by AI, up to 12 months

    The center of a tooth automatically determined by computer

  3. 3D position of tooth

    Time frame: Outcome will be measured when 75% of training models were studied by AI, up to 18 months

    The center of a tooth automatically determined by computer

  4. 3D position of tooth

    Time frame: Outcome will be measured after the whole training, which AI was trained of 100% of all models, up to 24 months

    The center of a tooth automatically determined by computer

  5. Occlusal morphology of tooth

    Time frame: Outcome will be measured when 25% of training models were studied by AI, up to 6 months

    The cusps (highest point) and the fossa (lowest point) of the occlusal surface

  6. Occlusal morphology of tooth

    Time frame: Outcome will be measured when 50% of training models were studied by AI, up to 12 months

    The cusps (highest point) and the fossa (lowest point) of the occlusal surface

  7. Occlusal morphology of tooth

    Time frame: Outcome will be measured when 75% of training models were studied by AI, upto 18 months

    The cusps (highest point) and the fossa (lowest point) of the occlusal surface

  8. Occlusal morphology of tooth

    Time frame: Outcome will be measured after the whole training, which AI was trained of 100% of all models, upto 24 months

    The cusps (highest point) and the fossa (lowest point) of the occlusal surface

  9. Time spent in laboratory design and in clinical deliver of denture prostheses

    Time frame: Outcome will be measured after the whole training, which AI was trained of 100% of all models, upto 24 months

    Time (in minutes) spend in a) design and b) deliver of dental prostheses

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Collaborators

  • University Grants Committee, Hong Kong

Registry information

Official study title

Artificial Intelligence in Prosthodontics - Design of Maxillary Single-tooth Dental Prostheses

Important dates

Study start
2021
Primary completion
2024
Study completion
2025
First posted
Sep 27, 2021
Registry last updated
Oct 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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