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OpenTrials
Completed

NCT Number: NCT01476865

Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients

The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of rheumatoid arthritis.

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Key information

Conditions

Disorders of Synovium, Multiple Sites Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Disorders of Cartilage, Hand Joints Disorders of Subchondral Bone, Multiple Sites Healthy People Immune System Diseases Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

About this study

Rheumatoid arthritis (RA) is a chronic inflammatory, systemic and auto-imune disorder affecting primarily the joints. In RA, inflammatory synovium causes destruction of cartilage, erosion of the adjacent bone and ultimately loss of function of the affected joint. Newer imaging techniques, such as ultrasound (US), have shown promise in evaluation of RA. Many US scoring system have been used to classify and quantify the synovium, effusion, erosion and cartilage for assessing and monitoring AR. However, its use is considered problematical because there are very few data on normal joints and, at this point, there is no clear definition of excess amount of synovium in normal people.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • no articular disease (healthy group)
  • establish rheumatoid arthritis (RA group)

Exclusion criteria

  • diabetes
  • hypothyroidism- hemophilia
  • pregnancy
  • previous septic arthritis
  • previous articular surgery
  • symptomatic osteoarthritis
  • no superimposed collagenoses (RA group)

Sponsors and collaborators

Lead sponsor

Federal University of São Paulo

Other

Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Official study title

Articular Sonography: Findings in Healthy Subjects Compared With Rheumatoid Arthritis Patients

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Nov 22, 2011
Registry last updated
Nov 22, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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