Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

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Key information

Conditions

Disorders of Consciousness Brain Diseases Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Consciousness Disorders Ischemic Attack, Transient Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Transient Ischemic Attack Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Zhejiang University

Hanzhou, Zhejiang, 310003, China

About this study

Background:It is unclear what substances the brain needs to ingest for its activity under pathological conditions

Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1.Patients with consciousness disorder caused by various severe brain injuries

Exclusion criteria

Patients who have been judged brain dead
There are persistent epileptic activity, inhibition or seizure inhibition patterns
Recent fever, abnormal liver and kidney function
Previous history of neurological or mental illness
Have a history of tumor
Inflammatory bowel diseases, hyperlipidemia, gastritis

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

Patient clinical outcome

Time frame: 12 months

The patients were followed up for 12 months after blood collection to observe the clinical outcome

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital of Zhejiang University

Other

Registry information

Official study title

Arteriovenous Plasma Multiomics and Inflammatory Factors in Patients With Disorders of Consciousness

Important dates

Study start: 2022
Primary completion: 2024
Study completion: 2024
First posted: May 7, 2024
Registry last updated: May 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed