Arterial Stiffness, Wave Reflections and Renal Failure

1. Cardiovascular risk is high in patients with renal failure. 2. Cross-sectional studies have indicated a relationship between arterial stiffness and renal function. However, there are no prospective longitudinal studies in the literature. 3. In dialysis patients, arterial stiffness as well as wave reflections, predict mortality. However, there are no data on patients with mild-to-moderate renal impairment available. 4. Therefore, we designed a study to test the hypothesis that: a) measures of arterial stiffness and wave reflections predict the progression of renal impairment in patients with mild-to-moderate renal failure; and b) measures of arterial stiffness and wave reflections predict cardiovascular events in patients with mild-to-moderate renal failure

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Key information

Conditions

Chronic Renal Failure Arterial Stiffness Arterial Wave Reflections Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Cardiology and Nephrology Department Klinikum Wels

Wels, 4600, Austria

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

chronic renal failure patients (KDOQI III, IV) undergoing regular control visits at our nephrology department
> 19 years
written informed consent

Exclusion criteria

atrial fibrillation
valvular heart disease
severely impaired systolic function
no informed consent

Treatment and study plan

Primary outcomes

renal endpoint

doubling serum creatinine, need for dialysis, renal transplantation

Sponsors and collaborators

Lead sponsor

Klinikum Wels-Grieskirchen

Other

Registry information

Official study title

Observational Study on the Prognostic Significance (Renal and Cardiovascular) of Arterial Stiffness and Arterial Wave Reflections in Patients With Mild to Moderate Renal Impairment

Important dates

Study start: 2006
Primary completion: 2010
Study completion: 2010
First posted: Jul 20, 2006
Registry last updated: Nov 4, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed