Arterial Stiffness in Chronic Kidney Disease

Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Chronic Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year–79 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinical Research Centre, 2nd Floor Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Systolic blood pressure <160 whether or not on antihypertensive medication
diastolic blood pressure <100mmHg whether or not on antihypertensive medication
Chronic kidney disease stage 2-5

Exclusion criteria

Systolic blood pressure ≥160mmHg
Diastolic blood pressure ≥100mmhg
Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)

Treatment and study plan

Primary outcomes

Diurnal variations in arterial stiffness

Time frame: Over one 26 hour period arterial stiffness measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am

The principal objective of this study is to evaluate whether diurnal variations in arterial stiffness are blunted in chronic kidney disease compared to healthy age matched controls

Secondary outcomes

Diurnal variations in aortic and brachial blood pressure

Time frame: Over one 26 hour period blood pressure measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am

Secondary objective of this study is to evaluate whether diurnal variations in aortic and brachial blood pressure are blunted in chronic kidney disease compared to healthy age matched controls
Relationship between changes in blood pressure and arterial stiffness

Time frame: Over one 26 hour period

Secondary objective of this study is to evaluate whether diurnal variations in arterial stiffness are dependent on changes in blood pressure in both chronic kidney disease patients and age matched controls.

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Registry information

Official study title

Diurnal Variations in Arterial Stiffness in Patients With Chronic Kidney Disease and Healthy Age Matched Controls

Important dates

Study start: 2012
Primary completion: 2013
First posted: Jan 18, 2013
Registry last updated: Nov 17, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed