Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT07176676

Aromatherapy Treatment With Lavender Essential Oil to Reduce Post-Operative Nausea and Vomiting (PONV)

The aim of this study is to evaluate the effectiveness of aromatherapy through the use of inhaled Lavender oil in reducing patients' nausea during the post-operative period.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Conditions

PONV Nausea Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Nausea and Vomiting Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Trial Center

Alessandria, Italy, 15121

About this study

To evaluate the effectiveness of inhaling Lavender Angustifolia essential oil in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period.

Secondary objective

  • To detect the number of antiemetic administrations in the experimental arm compared to the control arm
  • To measure the patient satisfaction of patients in the experimental group with the Lavender essential oil aromatherapy intervention at hospital discharge Primary endpoint Reduction of nausea by at least 10% compared to treatment with standard care, as assessed by the NRS (Numerical Rating Scale).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who sign an informed consent
  • Patients who have undergone anesthesiological examination
  • Patients undergoing general anaesthesia
  • Clinically stable patients
  • Patients with nausea scores detected with NRS>0
  • Patients admitted undergoing surgery in the Complex and/or Simple Structures listed below:
  • SC of Neurosurgery, undergoing spinal surgery
  • SC of General Surgery, undergoing surgery on one of the organs of the abdominal cavity
  • SC of Vascular Surgery, undergoing traditional surgical repair or endovascular procedure of abdominal aortic aneurysm. Sclerotherapy (to heal varicose veins) venous stripping (removal of a vein segment in the treatment of varicose veins) laser treatment
  • SS of Gynaecological Surgery, undergoing operations on the organs of the female genital apparatus.

Exclusion criteria

Patients with ongoing relevant cognitive impairment (Six Item Screener score <4)

  • Patients with allergies or sensitivities to lavender essential oils
  • Patients with asthma, COPD, Chronic Bronchitis, Obstructive Sleep Apnea
  • Patients with changes in sense of smell

Treatment and study plan

Lavanda Angustifolia essential oil

Other

Administration of Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period.

Usual Care

Other

Patients in the Usual Care group will follow the standard procedure, which consists of administering antiemetics if provided in therapy or reporting to the doctor with a subsequent treatment decision

Primary outcomes

  1. To evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period

    Time frame: during the 24-hour post-operative period

    To reduce nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period.

    Endpoint Reduction of nausea by at least 10% compared to treatment with standard care, as assessed by the NRS (Numerical Rating Scale).

Secondary outcomes

  1. To evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period

    Time frame: during the 24-hour postoperative period

    To measure the number of antiemetic administrations in the experimental arm compared to the control arm

  2. o evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period

    Time frame: during the 24-hour postoperative period

    To measure the patient satisfaction of the patients in the experimental group regarding the aromatherapy intervention with Lavender essential oil at hospital discharge

Sponsors and collaborators

Lead sponsor

Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria

Other

Registry information

Official study title

Evaluation of the Efficacy of an Aromatherapy Treatment With Lavender Essential Oil to Reduce Post-Operative Nausea and Vomiting (PONV): Two-arm, Non-pharmacological, Single-centre, Non-profit, Randomised Controlled Trial

Acronym: Leo-PONV

Important dates

Study start
2022
Primary completion
2024
Study completion
2025
First posted
Sep 16, 2025
Registry last updated
Sep 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.