Argatroban Plus R-tPA for Acute Ischemic Stroke

Inclusion criteria

• 18-80 years old;
• Time from onset to treatment ≤4.5 hours;
• NIHSS ≥ 6
• Diagnosis of ischemic stroke
• Signed informed consent by patient self or legally authorized representatives.

Exclusion criteria

• mRS≥2;
• History of stroke within 3 months;
• History of intracranial hemorrhage;
• Suspected subarachnoid hemorrhage;
• Intracranial tumour, vascular malformation or arterial aneurysm;
• Major surgery within 1 month;
• Systolic pressure ≥180 mmHg or diastolic pressure ≥110 mmHg;
• Platelet count < 105/mm3;
• Heparin therapy or oral anticoagulation therapy within 48 hours;
• Abnormal APTT;
• Thrombin or Xa factor inhibitor;
• Severe disease with a life expectancy of less than 3 months;
• Blood glucose < 50 mg/dL (2.7mmol/L);
• Patients who have received any other investigational drug or device within 3 months;
• Pregnancy;
• Researchers consider patients inappropriate to participate in the registry.