Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

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Key information

Conditions

Carotid Stenosis Arterial Occlusive Diseases Brain Diseases Cardiovascular Diseases Carotid Artery Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chu Dijon Bourgogne

Dijon, 21000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who have provided explicit consent
Patients older than 18 years
Patients about to undergo surgery for carotid stenosis
Haemoglobin ≥ 7g/dl at the time the sample is taken
Respect the maximum volume of blood taken (treatment + research) in 30 days

SPECIFIC TO DIABETICS

Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier

Exclusion criteria

Patients under guardianship
Patients without health insurance cover
Pregnant or breast-feeding women

Treatment and study plan

Blood samples

Procedure

3 tubes (5 ml volume) collected during surgery

recover samples of atheromatous plaque

Procedure

a carotid sample collected during surgery

Primary outcomes

Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects

Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Dijon

Other

Registry information

Acronym: MASCADI

Important dates

Study start: 2017
Primary completion: 2020
Study completion: 2020
First posted: Jun 29, 2017
Registry last updated: Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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