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NCT Number: NCT06831110

Aquagenic Wrinkling Prediction

The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.

Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.

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Key information

Conditions

Aquagenic Wrinkling of Palms Carrier State

Age range

18 year–24 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Iowa

Iowa City, Iowa, 52242, United States

Location status: Recruiting

Location contact

Shelby Francis, PhD

CONTACT

[email protected]

319-678-8037

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Interested in participating in other CF Carrier-related research studies.

Exclusion criteria

  • CF patient status
  • Unable to speak English
  • Unable to provide written informed consent
  • Prisoner status
  • An open wound on either hand
  • A tattoo on either hand
  • Missing any portion of either hand
  • Diagnosis of Diabetes
  • Diagnosis of Hyperhidrosis
  • Diagnosis of Raynaud's Disease
  • Diagnosis of Atopic Dermatitis
  • Regularly taking ACE inhibitors or angiotensin receptor blockers

Treatment and study plan

Aquagenic Wrinkling

Procedure

Participants will be asked to remove all jewelry from the hand(s) and wrist(s) that will be undergoing the aquagenic wrinkling procedures. Photographs will be taken of the palmar surface of the hand(s). The participant will submerge the hand(s) undergoing testing in a water bath for one minute. After one minute, they will remove their hand(s), dry them gently with a towel, and photographs will be taken of the palmar surface of the hand(s). The participant will re-submerge their hand(s) in the appropriate conditions for another minute and the process will be repeated 20 times for 20 total minutes submerged in the water.

Primary outcomes

  1. Human Observation of Wrinkling

    Time frame: Up to 20 minutes

    Photos of hands will be scored on a scale of 0 (no wrinkling) to 4 (severe wrinkling) at each minute by human observers.

  2. Machine-Learning Observation of Wrinkling

    Time frame: Up to 20 minutes

    Photos of hands will be scored by a machine-learning algorithm at each minute.

Study contacts

Contact information is provided by the study sponsor or research team.

Philip M Polgreen, MD

CONTACT

[email protected]

319-384-6194

Shelby L Francis, PhD

CONTACT

[email protected]

319-678-8037

Sponsors and collaborators

Lead sponsor

University of Iowa

Other

Registry information

Official study title

Using Aquagenic Wrinkling to Predict CF Carrier State

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 17, 2025
Registry last updated
Jun 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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