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NCT Number: NCT07434635

APPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes

The study will evaluate whether atropine eyedrops are beneficial when used after certain eye surgeries.

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Key information

Conditions

Eye Disorders Eye Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of California, San Francisco

San Francisco, California, 94143, United States

Location status: Recruiting

Location contact

Jay Stewart

CONTACT

[email protected]

415-353-9635

About this study

Atropine eyedrops are often used after certain eye surgeries. This study will compare several outcomes following surgery in patients either using or not using this treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient undergoing vitrectomy surgery
  • able to give informed consent

Exclusion criteria

  • post-operative eyedrop regimens that include topical non steroidal anti-inflammatory medications
  • subjects with altered post-operative eyedrop schedule for enhanced inflammation control
  • documented allergy to atropine

Treatment and study plan

Atropine 1%

Drug

Subtraction of atropine eyedrops from post-operative treatment regimen

Other names: Atropine

Primary outcomes

  1. Pain score on the Visual Analog Scale (VAS)

    Time frame: 1 month

    Whether atropine use impacts post-operative pain score on the standard Visual Analog Scale (VAS)

Secondary outcomes

  1. Anterior chamber inflammation (aqueous cell and flare)

    Time frame: 1 month

    Whether atropine impacts the occurrence of post-operative inflammation, quantified as aqueous cell and flare, using the Standardization of Uveitis Nomenclature (SUN) Criteria

  2. Cystoid macular edema detected by optical coherence tomography

    Time frame: 1 month

    Whether atropine impacts the occurrence of cystoid macular edema after surgery, detected by optical coherence tomography scanning of the retina

  3. Time to visual recovery

    Time frame: 1 month

    Whether atropine impacts the time to visual recovery

  4. Intraocular pressure

    Time frame: 1 month

    Whether atropine impacts intraocular pressure after surgery

  5. Posterior synechiae formation

    Time frame: 1 month

    Presence or absence of posterior synechiae assessed by slit lamp examination at post-operative visits

Study contacts

Contact information is provided by the study sponsor or research team.

Jay Stewart, MD

CONTACT

[email protected]

415-353-9635

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Acronym: APPRAISE

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Feb 25, 2026
Registry last updated
Jul 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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