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Completed

NCT Number: NCT02594605

Applied The Platelet Rich Fibrin in Chronic Periodontitis

Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

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Key information

Conditions

Chronic Periodontitis Chronic Disease Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Alper KIZILDAĞ

Denizli, 20010, Turkey (Türkiye)

About this study

PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after Phase I therapy

Exclusion criteria

  • The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months

Treatment and study plan

Platelet Rich Fibrin

Device

Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.

Conventional Flap Surgery

Device

Only Conventional Flap Surgery treatment the bone loss limitedly.

Primary outcomes

  1. Levels of IGF-1, VEGF, BMP-2, FGF-2 on Weekly

    Time frame: 4 weeks

    Change from baseline IGF-1, VEGF, BMP-2, FGF-2 levels of GCF at 1 month were measured by periopaper.

Secondary outcomes

  1. Alteration of Clinical Attachment Level

    Time frame: 6 month

    Change from baseline Clinical Attachment Levels at 6 months were measured with periodontal probe.

  2. Alteration of Periodontal Pocket Depth

    Time frame: 6 month

    Change from baseline Pocket Depth at 6 months were measured with periodontal probe.

Sponsors and collaborators

Lead sponsor

Ataturk University

Other

Registry information

Official study title

Investigation of the Contributions of Platelet Rich Fibrin Combined With Conventional Periodontal Flap on Periodontal Healing

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Nov 3, 2015
Registry last updated
Aug 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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