Skip to main content
OpenTrials
Completed

NCT Number: NCT03997240

Applied Clinical Neuroscience Care for Self-reported Symptoms of Depression and Cerebellar Function in Adults

Pilot study design that operationalizes the multimodal manner of care while evaluating changes in depression symptoms, dysmetria, and balance for medication non-responders.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

NeuroLife Institute

Marietta, Georgia, 30060, United States

About this study

Pilot study design that operationalizes the multimodal manner of care while evaluating changes in depression symptoms, dysmetria, and balance for medication non-responders. This research will provide an initial first step towards answering the following three research questions:

  • Does a multimodal chiropractic applied clinical neuroscience approach to care affect self-reported symptoms of depression?
  • Does a multimodal chiropractic applied clinical neuroscience approach to care affect dysmetria and balance control in a clinically depressed population?
  • Are changes in dysmetria and balance control correlated with a change in depressive symptoms.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • You are over the age of 18.
  • You have been diagnosed with depression.
  • You are currently taking medication for depression or have previously taken medication.
  • You have been or were on your depression medication for at least 3 months.
  • You feel/felt that the medication is/was not helping.

Exclusion criteria

  • Had a lifetime history of severe neurologic or mental illness (e.g. schizophrenia or substance abuse)
  • Are pregnant
  • Have pending litigation or a recent history of spinal fracture, metastatic cancer, chiropractic care within the past month
  • Present with contraindications to chiropractic care

Treatment and study plan

Chiropractic Applied Clinical Neuroscience

Procedure

Chiropractic Applied Clinical Neuroscience makes use of chiropractic care in addition to application of therapies designed to stimulate multisensory reintegration and cerebellar coordination. The multisensory reintegration and cerebellar therapies make use of the body's own sensory receptors as a target, with the purpose of realigning the brain's interpretation of different afferent signals. Observation of motor and autonomic output patterns during and after sensory stimulation afford the clinician real-time feedback, providing for adaptation of the sensory based protocol.

Primary outcomes

  1. P300 Auditory Evoked Potential task

    Time frame: 20 minutes

    Time-locked electroencephalography recording of the P300 event related potential. P300 testing involves placing electrodes on the participant's scalp while the individual is listening to a series to two different tones through headphones.

Secondary outcomes

  1. Shift Balance Platform

    Time frame: 10 minutes

    Limits of stability test: For the limits of stability test the participant will be asked to lean forward, backward, left, and right. The participant will lean slowly in each direction at a self-determined speed and to a point where he or she feels is the maximum leaning distance without falling. The tests should take about 2 minutes but will vary based on the participant.

Sponsors and collaborators

Lead sponsor

Life University

Other

Registry information

Official study title

A Randomized Wait-list Control Trial Evaluating the Effect of Team-based Applied Clinical Neuroscience Care on Self-reported Symptoms of Depression and Cerebellar Function in Adults With Medication-resistant Depression

Acronym: DEP

Important dates

Study start
2019
Primary completion
2023
Study completion
2023
First posted
Jun 25, 2019
Registry last updated
Feb 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.