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OpenTrials
Completed

NCT Number: NCT02354248

Application of the Triple Stimulation Technique to Patients With CNS Disorders Including Stroke

TST (Triple stimulation technique) helps to better quantify the proportion of motor units activated by transcranial magnetic stimulation. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise with this technique than with the slowing of the central conduction time (CCT).

The investigators propose to use this technique in CNS pathologies where this disorder is significant and essential, like multiple sclerosis and stroke.

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Key information

Conditions

Stroke Patients

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Brugmann

Brussels, 1020, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • stroke patients with hemiparesia

Exclusion criteria

  • pace maker
  • epilepsia
  • metallic neurosurgical implants

Treatment and study plan

Triple stimulation technique

Procedure

Evoked motor potentials obtained by magnetic transcranial stimulation are usually used, in standard practice, to evaluate the corticospinal tract. This procedure combines two techniques: the magnetic stimulation and the electroneuromyography. It is based on the double collision principle between the descending central stimulation (magnetic) and the ascending peripheric stimulation, hereby suppressing the issue of desynchronisation of evoked motor potentials. The Triple stimulation technique allows a better quantification of the proportion of motor units activated by the transcranial stimulation.

Primary outcomes

  1. Amplitude of the motor evoked potentials

    Time frame: during the TST (30 min)

  2. Surface of the motor evoked potentials

    Time frame: during the TST (30 min)

  3. Amplitude ratio of the TST

    Time frame: during the TST (30 min)

  4. Surface ratio of the TST

    Time frame: during the TST (30 min)

  5. TMS threshold

    Time frame: during TST (30 min)

Sponsors and collaborators

Lead sponsor

Brugmann University Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Feb 3, 2015
Registry last updated
Jan 23, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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