Application of in Vivo Splitting Technique in Adult Liver Transplantation

The feasibility of split liver transplantation (SLT) remains controversial. This study aimed to evaluate the outcomes of SLT in adult recipients and to identify specific areas of improvements. A retrospective analysis was conducted on adults who underwent full size SLT between January 2021 and December 2023. The short-term outcomes of these patients who underwent SLT were compared with those of patients who underwent whole liver transplantation (WLT) during the same period.

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Key information

Conditions

Liver Transplantation

Age range

16 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ningbo Medical Centre Lihuili Hospital

Ningbo, Zhejiang, 315000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For the donor graft:

age of 18-60 years;
BMI of 19-28 kg/m2;
hemodynamic stability or use of a single vasoactive drug with a small dosage (norepinephrine ≤ 0.1 μg/kg/min or dopamine ≤ 5 μg/kg/min);
liver steatosis ≤ 10%;
liver functional indicators (ALT, AST, total bilirubin quantification) ≤ 3 times the normal value;
blood sodium ≤ 160 mmol/L;

For the SLT recipients

Patients who had registered in the China Organ Transplant Response Systems.
Initial liver transplantation.
Graft-to-Recipient Weight Ratio (GRWR) ≥ 1%.

Exclusion criteria

For the donor graft

uncontrollable infection
significant vascular and biliary variation.

For the recipients

Severe portal hypertension.
Significant vascular variation.

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

Overall survival

Time frame: 2021.01.01-2025.12.31

the overall survival of liver transplant recipient during study period

Secondary outcomes

Postoperative complications

Time frame: 2021.01.01-2025.12.31

Postoperative complications of liver transplant recipient during study period

Sponsors and collaborators

Lead sponsor

Ningbo Medical Center Lihuili Hospital

Other Gov

Registry information

Official study title

Application of in Vivo Splitting Technique of Brain-dead Donor Liver in Adult Liver Transplantation

Important dates

Study start: 2021
Primary completion: 2025
Study completion: 2025
First posted: Apr 13, 2025
Registry last updated: Apr 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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