Application of Enteral Nutrition Program in Patients With Intra-abdominal Hypertension Oriented by Intra-abdominal Pressure

Background: Enteral nutrition is the preferred method of artificial nutrition for critically ill patients. Early enteral nutrition within 24 to 48 hours after admission can maintain intestinal mucosal barrier function, increase local blood flow, reduce bacterial migration, and reduce the incidence of intestinal infections. Increased abdominal pressure is considered to be an independent risk factor for feeding intolerance in severe patients. Patients with abdominal pressure are prone to complications such as diarrhea, abdominal distension, vomiting, and even aspiration, which forces the suspension or suspension of enteral nutrition and leads to insufficient nutritional intake in patients. At present, there is evidence that regulating enteral nutrition through monitoring intra-abdominal pressure can effectively reduce the incidence of feeding intolerance in patients. Domestic and foreign scholars have formulated nutrition management programs for patients with intra-abdominal pressure from different aspects, such as monitoring and grading of intra-abdominal pressure, evaluation and management of tolerance, and prevention of complications. However, The standardized enteral nutrition feeding program oriented by the monitoring of intra-abdominal pressure has not yet formed a unified standard.

Objective: This study conducted a quality evaluation based on existing evidence, adopted evidence-based research methods to establish an enteral nutrition program for patients with abdominal hypertension oriented by abdominal pressure, and aimed to improve the feeding tolerance of patients with abdominal hypertension, improve the nutritional compliance rate and improve the prognosis of patients through the implementation of evidence-based practice programs.

• Inclusion Criteria

• 12mmHg≤ intraperitoneal pressure ≤20mmHg (1mmHg=0.133kPa)
• ≥18 years of age
• Consistent with the indications of early enteral nutrition

• Patients with nutritional risk, gastrointestinal function, or partial gastrointestinal function and unable to eat through the mouth

• Stable hemodynamics (MAP > 65mmHg, blood lactic acid < 4mmol/L, and vasoactive drugs in the process of reduction or withdrawal)
• Patients or their family members sign the informed consent
• Exclusion Criteria

• Pregnant or lactating female patients
• Patients with recent abdominal surgery
• Patients with a large number of abdominal effusions;
• There are contraindications to enteral nutrition

• Uncontrolled shock

• Uncontrolled hypoxemia and acidosis

• Uncontrolled upper gastrointestinal bleeding

• GRV > 500mL/ 6h

• Intestinal ischemia

• Intestinal obstruction

• Abdominal space syndrome (ACS)

• High fistula without distal feeding