Application of Early Goal-directed Sedation in Patients With Severe Brain Injury

EGDS management strategy was implemented in ICU patients with severe brain injury, the depth of sedation and GCS score were monitored, and the protective effects of EGDS strategy and standard sedation strategy on the brain of patients with severe brain injury were discussed.

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Key information

Conditions

Brain Injuries, Traumatic Brain Diseases Brain Injuries Central Nervous System Diseases Craniocerebral Trauma Nervous System Diseases Trauma, Nervous System Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of severe craniocerebral injury
The GCS score is 6 to 12 points
Within 12 hours of intubation
The mechanical ventilation time is greater than 24 hours
Obtain written consent

Exclusion criteria

Pregnant women
Acute liver failure
Dementia or mental illness

Treatment and study plan

Early goal-directed sedation programs

Other

A. Provide sedation at the beginning of the titration of dextrometomidine; b. Optimize sedation when dextrometomidine is used alone and at a maximum dose not sufficient to provide comfort and safety to the patient and to achieve a level of sedation at any time specified by the treating physician. C. Provides immediate recovery and sedation, and can control sudden agitation at any time

Primary outcomes

Richmond Agitation-Sedation Scale

Time frame: through study completion, an average of 2 year
Mechanical ventilation time

Time frame: through study completion, an average of 2 year
length of stay in ICU

Time frame: through study completion, an average of 2 year

Secondary outcomes

complication

Time frame: through study completion, an average of 2 year

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Aug 25, 2020
Registry last updated: Aug 25, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed