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Completed

NCT Number: NCT02084368

Application of Combined Lumbar Plexus and Sciatic Nerve Block

The research is to study the effectiveness and safety of combined lumbar plexus and sciatic nerve block by the guide of peripheral nerve stimulator (PNS) in unilateral knee replacement.There have be some papers which supported that combined lumbar plexus and sciatic nerve block may be more suitable for the old men.

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Key information

Conditions

Anesthesia

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Guangzhou Military Region General Hospital, Department of Anesthesiology

Guangzhou, Guangdong, 510010, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of American Association of anesthetists（ASA）Grade 1、2 or 3
  • Aged between 18 and 85 years
  • Undergoing elective total knee replacement.

Exclusion criteria

  • Mental illness can not match
  • Nerve block, epidural anesthesia contraindicated
  • People who have Slow-type arrhythmias
  • History of chronic headaches and long-term use of analgesic drugs
  • People who were postoperative consciousness, language or hearing impaired

Treatment and study plan

Nerve Block

Procedure

Patients in this group were assigned to receive lumbar plexus block and sciatic nerve block both using 0.33% ropivacaine 30ml guided by PNS

Combined spinal and epidural anesthesia

Procedure

Combined spinal and epidural anesthesia were performed in patients of this group with 0.5% hyperbaric bupivacaine 8~10mg at L2-3 or L3-4.

Ropivacaine

Drug

Patients will be assigned to receive lumbar plexus block and sciatic nerve block both using 0.33% ropivacain 30ml guided by PNS.

Other names: 0.33%Ropivacaine

Bupivacaine

Drug

Combined spinal and epidural anesthesia will be performed in patients with 0.5% hyperbaric bupivacaine 8~10mg.

Other names: 0.5%Bupivacaine

Primary outcomes

  1. Maintenance time of sensory and motor nerve block

    Time frame: up to 24h after operation

    from the end of injection of local anesthetic drug up to 24h after operation

Secondary outcomes

  1. The change of hemodynamics

    Time frame: 0, 5, 10, 20, 30, 60 min after injection

    the changes of SBP and DBP at 0, 5, 10, 20, 30, 60 min after injection

Sponsors and collaborators

Lead sponsor

Guangzhou General Hospital of Guangzhou Military Command

Other

Registry information

Official study title

Application of Combined Lumbar Plexus and Sciatic Nerve Block in Unilateral Knee Replacement

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Mar 12, 2014
Registry last updated
Sep 11, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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