Application of an Electronic Nose in the Early Detection of ASpergillosis

The purpose of this study is to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls.

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Key information

Conditions

Pulmonary Invasive Aspergillosis Aspergillosis Bacterial Infections and Mycoses Infections Invasive Fungal Infections Invasive Pulmonary Aspergillosis Lung Diseases Lung Diseases, Fungal Mycoses Pulmonary Aspergillosis Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Hematology, Academic Medical Center

Amsterdam, 1100 DD, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients that

are 18 years of age or older
will undergo treatment for a hematological malignancy expected to result in grade 4 neutropenia (according to CTCAE 3.0, i.e. <0.5 x 109 neutrophils/L) of prolonged duration (i.e., more than 7 days), e.g. hematopoietic stem cell transplantation or induction/consolidation treatment for acute myeloid leukaemia
have given written informed consent

Exclusion criteria

a previously diagnosed invasive mycosis
the inability to perform the breathing manoeuvre needed for eNose-analysis of exhaled air

Treatment and study plan

Primary outcomes

accuracy with which the Cyranose can discriminate between patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls with fever

Time frame: 4 days

The cross-validated accuracy with which the Cyranose can discriminate between patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls with fever, defined as the percentage of correctly classified patients using the leave-one out method

Sponsors and collaborators

Lead sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Other

Registry information

Official study title

The Application of an Electronic Nose in the Early Detection of ASpergillosis

Acronym: AENEAS

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2012
First posted: Jul 15, 2011
Registry last updated: Jun 24, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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