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NCT Number: NCT06469086

Appendicoliths in Acute Complicated Appendicitis Patients With Abscess

Complicated appendicitis, characterized by the presence of an abscess or perforation, involves acute inflammation of the peritoneum secondary to an infection of the appendix, presenting additional challenges for management. Traditionally, the standard treatment for complicated appendicitis has been surgical intervention. However, conservative management, involving antibiotics and drainage, has emerged as a viable alternative for selected patients. Recent studies emphasize the importance of selecting appropriate antibiotics based on local resistance patterns and the patient's clinical condition. Broad-spectrum antibiotics, including those targeting anaerobic bacteria, are often preferred. In addition, advances in imaging technology, such as ultrasound-guided drainage, have improved the precision and success rates of percutaneous abscess drainage. This minimally invasive approach helps manage localized infections and can prevent the need for immediate surgery.

One factor that has gained significant attention in determining the success of conservative treatment for acute complicated appendicitis is the presence of appendicoliths-calcified deposits within the appendix. This study aims to investigate the clinical significance of appendicoliths in the conservative management of acute complicated appendicitis with abscesses.

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Key information

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who aged ≥18 years, who diagnosed as acute appendicitis clinically, who had peri-appendiceal abscess larger than 2 cm in diameter on CT scan, who agreed conservative treatment first, who refused immediate emergency surgery

Exclusion criteria

  • Patients younger than 18 years, those with malignancies, those with incomplete clinical or pathological records were excluded from the study

Treatment and study plan

Clinical data collection

Other

The clinical significance of appendicoliths in the conservative management of acute complicated appendicitis with abscesses.

Primary outcomes

  1. The success rate of conservative treatment

    Time frame: January 01, 2025 to December 31, 2025.

Secondary outcomes

  1. Postoperative complications

    Time frame: January 01, 2025 to December 31, 2025.

  2. Length of postoperative hospital stay

    Time frame: January 01, 2025 to December 31, 2025.

  3. The surgical approach used

    Time frame: January 01, 2025 to December 31, 2025.

Sponsors and collaborators

Lead sponsor

Shanghai Zhongshan Hospital

Other

Registry information

Official study title

Clinical Significance of Appendicoliths in Conservative Treatment of Acute Complicated Appendicitis Patients With Abscess: A Single-center Retrospective Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jun 21, 2024
Registry last updated
Jun 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.