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Completed

NCT Number: NCT02872818

Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia

The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.

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Key information

Conditions

Apoptotic Signal Pathways in Endometrial Hyperplasia Endometrial Hyperplasia Endometrial Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Neoplasms Neoplasms by Site Urogenital Diseases Urogenital Neoplasms Uterine Diseases Uterine Neoplasms

Age range

8 week–10 week

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Kayseri Training and Research Hospital

Kayseri, 38000, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Forty-eight weeks old female Wistar-Albino rats, weighting between 180 and 260 g

Exclusion criteria

.

We have no exclusion criteria because we examine drugs effects in the experimental rats

Treatment and study plan

17β estradiol hemihydrate

Drug

4mg/kg/day for 20 days

metformin

Drug

50 mg/kg/day last 10 days

Medroxyprogesterone Acetate

Drug

1mg/kg/day last 10 days

Primary outcomes

  1. Survivin Gene Expression Levels in Rat Uterine Tissue

    Time frame: 4 months

  2. Bcl-2 Gene Expression Levels in Rat Uterine Tissue

    Time frame: 4 months

  3. Bax Gene Expression Levels in Rat Uterine Tissue

    Time frame: 4 months

  4. c-Myc Gene Expression Levels in Rat Uterine Tissue

    Time frame: 4 months

  5. Caspase-9 Expression Levels in Rat Uterine Tissue

    Time frame: 4 months

Sponsors and collaborators

Lead sponsor

Kayseri Education and Research Hospital

Other Gov

Registry information

Official study title

The Effect of Metformin and Medroxyprogesterone Acetate on Apoptotic Signaling Pathways in Wistar-Albino Rats With Induced Endometrial Hyperplasia

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Aug 19, 2016
Registry last updated
Aug 23, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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