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NCT Number: NCT06069232

Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction

This study is a multicenter cohort study including patients diagnosed with aortic valve disease during hospitalization, including aortic insufficiency and aortic valve stenosis. The primary outcome of the study was all-cause death, and the secondary outcome was cardiovascular events. Through follow-up observation, the prognostic risk factors of patients with aortic disease were evaluated, and a prognostic model was constructed to guide clinical decision-making.

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Key information

Conditions

Aortic Valve Disease Aortic Valve Insufficiency Aortic Valve Stenosis Cardiovascular Diseases Heart Diseases Heart Valve Diseases Ventricular Outflow Obstruction

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China

Loading trial locations.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥ 18
  • diagnosed as aortic valve disease

Exclusion criteria

  • aortic valve replacement at baseline

Treatment and study plan

Primary outcomes

  1. all-cause mortality

    Time frame: from baseline to death or end of follow-up

    death caused by any cause

Secondary outcomes

  1. Cardiovascular death

    Time frame: from baseline to death or end of follow-up

    Death caused by cardiac causes

  2. Aortic valve replacement

    Time frame: from baseline to aortic valve replacement

    Transcatheter aortic valve replacement or surgical aortic valve replacement

Study contacts

Contact information is provided by the study sponsor or research team.

xiaodong zhuang, PhD

CONTACT

[email protected]

+86 13760755035

Sponsors and collaborators

Lead sponsor

Sun Yat-sen University

Other

Collaborators

  • Affiliated Hospital of Guangdong Medical University
  • Eighth Affiliated Hospital, Sun Yat-sen University
  • First Affiliated Hospital, Sun Yat-Sen University
  • Jieyang People's Hospital
  • Second Affiliated Hospital of Shantou University Medical College
  • Third Affiliated Hospital, Sun Yat-Sen University
  • Zhongshan People's Hospital, Guangdong, China

Registry information

Official study title

Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction (ARISTOTLE)

Acronym: ARISTOTLE

Important dates

Study start
2021
Primary completion
2028
Study completion
2028
First posted
Oct 5, 2023
Registry last updated
Oct 12, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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