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OpenTrials
Completed

NCT Number: NCT03072784

Aortic Cross Clamping Time, and Postoperative Respiratory Function

Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.

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Key information

Conditions

Bypass Complication Respiratory Complication

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Emad Zarief Kamel Said

Asyut, Asyut Governorate, 71111, Egypt

About this study

Cardiac surgery usually is done under cardiopulmonary bypass. As the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. Of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. Follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients
  • elective open heart surgery

Exclusion criteria

  • Patients with myocardial ischemia or previous infarction
  • low ejection fraction <30%
  • history of AF
  • implanted pacemaker
  • uncontrolled hypertension
  • renal impairment (creatinine >1.8 mg/dl)
  • hepatic dysfunction
  • insulin dependent diabetes
  • chronic pulmonary disease

Treatment and study plan

aortic cross clamping

Procedure

duration of cross clamping, less than 90 minutes, or more than 90 minutes

Primary outcomes

  1. quality of oxygenation

    Time frame: 48 hours postoperative

    PaO2 mmHg

Secondary outcomes

  1. time to extubation

    Time frame: 24 hours postoperative

    time to extubate in minutes

  2. ventilation

    Time frame: 48 hours postoperative

    respiratory rate (breath/minute)

  3. carbon dioxide

    Time frame: 48 hours

    PaCO2 mmhg

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Implication of Aortic Cross Clamping Time Upon Postoperative Respiratory Function in Adult Patients Undergoing Open Heart Surgery

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Mar 7, 2017
Registry last updated
Mar 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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