Skip to main content
OpenTrials
Completed

NCT Number: NCT05127928

Antioxidants Vitamins and Muscle Damage

Determine if acute supplementation with antioxidant vitamins (vitamin C and vitamin E) influences the muscle damage and fatigue caused after an acute session of eccentric training.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Oxidative Stress

Age range

18 year–33 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universidad Europea de Madrid

Madrid, Spain

About this study

A randomized, single-blind, placebo-control parallel trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria.

Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided. Participants will be divided in to groups and will performance one resistance exercise sessions. Prior to exercise, one group will intake supplementation VitC (1000 mg) + VitE (235 mg) and the other supplementation with placebo.

The following sequence will be performed in each session: 1) baseline assessment (analysis of the composition body, blood draw and parameters of performance) prior to exercise session ; 2) administration of vitamin or placebo supplementation 2 hours before exercise session ; 3) post-exercise assessments (blood biomarkers and performance parameters) immediately after the session and after 24 hours. DOMS will also be assessed 48 h and 72 h after training. The training session implemented will be designed by a Sport Scientific

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Physically active

Exclusion criteria

  • Injuries
  • Supplementation or drugs
  • Smokers

Treatment and study plan

Dietary Supplement: Vitamin C and vitamin E

Dietary Supplement

Antioxidant supplementation

Other names: Ascorbic acid and tocopherol

Placebo

Dietary Supplement

Placebo administration

Primary outcomes

  1. Percentage of body fat and muscle mass

    Time frame: Prior to the intervention

    Determination of body composition using skinfolds measurements

  2. DOMS

    Time frame: 0 hours post exercise

    Delayed onset muscle soreness. This outcome will be measure with a 10-point visual analogic scale (0= no pain; 10 = worst possible pain)

  3. DOMS

    Time frame: 24 hours post exercise

    Delayed onset muscle soreness. This outcome will be measure with a 10-point visual analogic scale (0= no pain; 10 = worst possible pain)

  4. Blood malondialdehyde (MDA)

    Time frame: 2 hours prior to exercise

    MDA will be analyzed from a blood sample

  5. Blood creatine quinase (CK)

    Time frame: 2 hours prior to exercise

    CK will be analyzed from a blood sample

  6. Blood malondialdehyde (MDA)

    Time frame: Inmediatly after exercise

    MDA will be analyzed from a blood sample

  7. Blood malondialdehyde (MDA)

    Time frame: 24 hours after exercise

    MDA will be analyzed from a blood sample

  8. Blood creatine quinase (CK)

    Time frame: 24 hours after exercise

    CK will be analyzed from a blood sample

  9. Jump height in a Counter Movement Jump

    Time frame: 2 hours prior to exercise

    Jump height (cm) in a counter movement jump measured with Octojump Platform

  10. Jump height in a Counter Movement Jump

    Time frame: Inmediatly after exercise

    Jump height (cm) in a counter movement jump measured with Octojump Platform

  11. Jump height in a Counter Movement Jump

    Time frame: 24 h after exercise

    Jump height (cm) in a counter movement jump measured with Octojump Platform

  12. Jump Height in a Squat Jump

    Time frame: 24 h after exercise

    Jump Height (cm) in a Squat Jump measured with Octojump Platform

  13. Jump Height in a Squat Jump

    Time frame: Inmediately after exercise

    Jump Height (cm) in a Squat Jump measured with Octojump Platform

  14. Jump Height in a squat Jump

    Time frame: 2 hours prior to exercise

    Jump height (cm) in a squat jump with Octojump Platform measured with Octojump Platform

  15. Jump Height in a Drop Jump

    Time frame: 2 hours prior to exercise

    Jump height (cm) was measured in different drop jumps with Octojump Platform

  16. Jump Height in a Drop Jump

    Time frame: Inmediately after exercise

    Jump height (cm) was measured in different drop jumps with Octojump Platform

  17. Contact time in a Drop Jump

    Time frame: Inmediately after exercise

    Contact time (s)measured in different drop jumps with Octojump Platform

  18. Jump Height in a Drop Jump

    Time frame: Inmediately after exercise

    Jump height (cm) measured in different drop jumps with Octojump Platform

  19. Contact time in a Drop Jump

    Time frame: 24 hours after exercise

    Contact time (s) measured in different drop jumps with Octojump Platform

  20. Jump Height in a Drop Jump

    Time frame: 24 hours after exercise

    Jump height (cm) measured in different drop jumps with Octojump Platform

  21. Contact time in a Drop Jump

    Time frame: Inmediately after exercise

    Capillary blood lactate evaluated with Lactate Pro 2

  22. Concentration of blood lactate

    Time frame: 2 hours before exercise

    Capillary blood lactate with Lactate Pro 2

Sponsors and collaborators

Lead sponsor

Universidad Europea de Madrid

Other

Registry information

Acronym: Antioxidant

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Nov 19, 2021
Registry last updated
Apr 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.