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Completed

NCT Number: NCT02494739

Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.

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Key information

Conditions

Oxidative Stress Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Physical Education & Sport Science of the University of Thessaly

Trikala, Karyes, 42100, Greece

About this study

Eighteen healthy adult volunteers of both sexes consumed yogurt (400g per day) enriched with polyphenols (10mg/100g yogurt) or yogurt (400g per day) not enriched with polyphenols for two weeks in a double-blind, crossover, randomized manner.There was a washout period of at least 10 days. Physiological data and blood samples were collected before and after consumption of each yogurt.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy individuals
  • Non-smokers

Exclusion criteria

  • Current use of dietary supplements or drugs
  • Metabolic disease
  • Lactose intolerance
  • Pregnant, pregnancy intention or breast feeding

Treatment and study plan

Yogurt enriched with polyphenols

Other

Yogurt enriched with polyphenols extracted from grape seeds

Yogurt not enriched with polyphenols

Other

Yogurt not enriched with polyphenols

Primary outcomes

  1. Antioxidant effects

    Time frame: Two weeks

    Indices of blood antioxidant status

  2. Anti-inflammatory effects

    Time frame: Two weeks

    Indices of inflammation in blood

Secondary outcomes

  1. Body composition

    Time frame: Two weeks

    Body fat percentage

  2. Blood pressure

    Time frame: Two weeks

    Blood pressure at rest

  3. Hydration

    Time frame: Two weeks

    Urine specific gravity

  4. Resting heart rate

    Time frame: Two weeks

    Resting heart rate

  5. Blood glucose levels

    Time frame: Two weeks

  6. Triglyceride levels

    Time frame: Two weeks

  7. Total cholesterol levels

    Time frame: Two weeks

  8. High Density Lipoprotein cholesterol levels

    Time frame: Two weeks

Sponsors and collaborators

Lead sponsor

University of Thessaly

Other

Registry information

Official study title

Investigation of the Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Jul 10, 2015
Registry last updated
Feb 2, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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