Skip to main content
OpenTrials
Completed

NCT Number: NCT04097899

Antimicrobial Stewardship Program and Ventilator Associated Pneumonia

Antibiotic Stewardship Programs (ASPs) help clinicians improve the quality of patient care and improve patient safety through increased infection cure rates, reduced treatment failures; however, there are different techniques, with variable results, of its application including what is called ASPs bundle and there is a need to investigate the effectiveness of implementing a comprehensive care bundle program including the key components of ASPs and the key items of infection control measures, this program can be called Antimicrobial Stewardship Comprehensive Care Bundle Program (ASCCBP).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Ventilator Associated Pneumonia Cross Infection Disease Attributes Healthcare-Associated Pneumonia Iatrogenic Disease Infections Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Ventilator-Associated Respiratory Tract Diseases Respiratory Tract Infections

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

About this study

Survey experimental study will be done in the first 6 months as regard antimicrobial drugs pattern and organism's sensitivity and resistance pattern in VAP patients.

In the next six months, clinical implementation of ASPs and infection control bundle will be applied on VAP patients. Then, in the later six months the investigators will study the outcome of VAP patients as regard:

  • Amount of cost of antibiotics.
  • Appropriates of antibiotic use (initiation, duration & time of discontinuation).
  • Rate of resistance
  • Clinical outcome, infection rate &length of stay.

Regular reports on antibiotic use and resistance will be admitted to relevant staff every one month. Also, audit and feedback about resistance and optimal prescribing will be applied every one month for ICU stuff as an open discussion.

The stewardship consulting team will include microbiologist with clinical experience in the field of antibiotic use and infection control. Stewardship team also will include the relevant ICU staff and an experienced clinical pharmacist.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients, ≥18 years, who were intubated and mechanically ventilated for more than 48 hours in ICU and showing clinical criteria of VAP

Exclusion criteria

  • Patients on immunosuppressive drugs.
  • Patient with chronic lung disease, chronic liver disease& chronic renal disease.
  • Immunocompromised Patients.
  • Patients intubated and mechanical ventilated outside the ICU before admission.
  • Patients manifested clinically with picture suggestive of VAP but less than 48 hours on mechanical ventilation.

Treatment and study plan

implementation of antimicrobial stewardship comprehensive care bundle program on ventilator associated pneumonia patients

Other

Construction of a comprehensive care bundle educational program. This program consisted of many elements: Antimicrobial stewardship programs, VAP bundles and infection control policy implementation and the investigators studied the impact of this program on:

  • Antibiotics cost.
  • Appropriates of antibiotic use (initiation, duration & time of discontinuation).
  • Rate of resistance
  • Clinical outcome, infection rate &length of stay.

Primary outcomes

  1. change in ventilator associated pneumonia incidence

    Time frame: 18 months

    After implementation of the Antimicrobial Stewardship Comprehensive Care Bundle Program (ASCCBP), the percentage of VAP incidence was measured to assess the effectiveness of the program.

  2. change in antibiotic resistance pattern

    Time frame: 18 months

    measuring the change in sensitivity and resistance pattern of antibiotics used in ICU was done by assessing the change in the sputum culture and sensitivity results.

Secondary outcomes

  1. ventilation days

    Time frame: 18 months

    Days of mechanical ventilation of each patient were measured to calculate the difference before and after implementation of the program.

  2. antibiotic cost

    Time frame: 18 months

    costs of antibiotics by Egyptian pounds were calculated to assess the effectiveness of the program

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Official study title

Impact of Implementation of Antimicrobial Stewardship Comprehensive Care Bundle Program on Ventilator Associated Pneumonia in Surgical Intensive Care Unit

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Sep 20, 2019
Registry last updated
Sep 20, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.