Antimicrobial Locks for Hemodialysis Catheter Infections

Tunneled hemodialysis catheters are susceptible to infection with high incidence of complication to the hemodialysis patients .The study aimed to prevent catheter infection through comparing use of antimicrobial solution (Taurolidine) when used as lock solution installed in the lumen of the catheter at the end of the hemodialysis session with the usually used lock solution heparin. The Study was performed on 100 hemodialysis patients over one year in Sohar hospital ,Oman .

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Key information

Conditions

Catheter Related Blood Stream Infection Catheter-Related Infections Hemodialysis Infections Vascular Access

Age range

13 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Sohar hospital

Sohar, 00968, Oman

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All clinically stable adult end stage renal disease patients commence regular hemodialysis through tunneled hemodialysis catheter at Sohar hospital hemodialysis unit.

Exclusion criteria

Patients with difficult vascular access and the tunneled hemodialysis catheter is the only functioning vascular access .
Patients with poor flow from the catheter.
Patients with active infection .
Patients have displayed allergic reactions to either citrate or taurolidine.
Patients were taking medication incompatible with either citrate or taurolidine

Treatment and study plan

Taurolidine citrate 4% and heparin 500

Drug

Taurolidine ,citrate 4% and heparin 500 units per ml used as lock solution in tunneled hemodialysis catheter

Primary outcomes

Comparison between both groups in terms of incidence of Catheter related blood stream infection

Time frame: one year

The investigators have studied the incidence of catheter related bacterial infection in both groups to determine superior effectiveness of Taurolidine lock solution than Heparin lock only in terms of prevention of infection .

Secondary outcomes

Comparison between both groups in terms of treatment cost

Time frame: one year

The secondary outcome measure was to compare the treatment cost in both groups to determine cost effectiveness

Sponsors and collaborators

Lead sponsor

Oman Ministry of Health

Other Gov

Registry information

Official study title

Effect of Tunneled Hemodialysis Catheter Antimicrobial Lock Solution in Prevention of Catheter Related Blood Stream Infection.

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Jul 20, 2025
Registry last updated: Jul 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed