Antihypertensive Treatment in Masked Hypertension

Inclusion criteria

• Age 30-70 years old
• Masked hypertension patients, defined as clinic BP<140/90 mmHg, while 24h ambulatory BP ≥130/80 mmHg and (or) daytime BP ≥135/85 mmHg and (or) nighttime BP ≥120/70 mmHg
• Combined with at least one kind of target organ damage: left ventricular hypertrophy (Cornell voltage combination ≥2440mm·ms or Sokolow-Lyon index ≥4.0mv for male and 3.5mv for female), large arterial stiffness (brachial-ankle pulse wave velocity ≥1400cm/s) and microalbuminuria (twice random urine microalbuminuria/creatinine ratio ≥2.5mg/mmol for male and 3.5mg/mmol for female).
• Didn't use any anti-hypertension drugs within 2 weeks
• Be willing to participate in the trials and able to finish clinic visits

Exclusion criteria

• Under antihypertensive treatment
• Secondary hypertension
• Taking other medications that may influence BP
• Sleep apnea syndrome
• Diabetes combined with microalbuminuria
• Renal parenchymal disease, such as chronic nephritis, polycystic kidney
• Occurrence of coronary heart disease, myocardial infraction or stroke within 6 months
• Structural heart disease, such as hypertrophic cardiomyopathy, dilated cardiomyopathy
• Alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBL) upper the twice of normal range, serum creatinine (Scr)≥2.0mg/dl, plasma hypokalemia≥5.5mmol/L,
• Patients have contraindications to angiotensin receptor blockers (ARBs)