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Completed

NCT Number: NCT03241316

Antibiotics and Activity Spaces: An Exploratory Study of Behaviour, Marginalisation, and Knowledge Diffusion

The investigators will conduct two rural surveys in Thailand and Lao PDR to improve the understanding of antibiotic-related health behaviour among the general population. One survey will capture a cross-section of health behaviours that is representative for the rural population in Chiang Rai (Thailand) and Salavan (Lao PDR), the other survey will create a two round village-level panel data set to study the evolution of health behaviours in the context of public engagement activities. The investigators will also collect complementary data about village-level infrastructure through observational check-lists, and collect secondary data on patient load from primary care units catering to their survey villages. As part of the questionnaire testing process, the investigators will conduct (and collect as primary data) cognitive interviews to improve the survey tool, to interpret their data, and to justify their methodological choices.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos

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About this study

The investigators will collect two data sets each in Lao PDR and Thailand: the first contains district-level representative health behaviour of approx. 2,400 adults across 30 rural communities per country (4,800 in total; representing rural populations of approx. 1-2 million adults); the second is a complete social network census of approx. 1600 adults each in three rural communities per country (approx. 4,800 in total). Within the sampled villages, the investigators will complete checklists about existing formal and informal healthcare facilities and gather patient load data from primary care units catering to the respective villages. As part of the questionnaire testing process, the investigators will conduct (and collect as primary data) cognitive interviews to improve the survey tool, to interpret our data, and to justify our methodological choices. The investigators will carry out the district-level village survey in one round, and the village-level social network censuses in two rounds. Between the two village social network censuses, the investigators will engage in public engagement activities in the selected villages (focused on antibiotic use) and re-survey all adults in the three villages per country two to three months later.

Objectives:

The primary objective is to improve the understanding of patients' antibiotic-related behaviour to support creative thinking about targeted and unconventional antimicrobial resistance (AMR) interventions in low- and middle-income countries (LMICs).

The investigators strive to achieve this primary objective by informing three research questions in Chiang Rai (Thailand) and Salavan (Lao PDR):

  • What are the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways?
  • Will people's exposure to antibiotic awareness activities entail changed behaviours that diffuse or dissipate within a network of competing healthcare practices?
  • Which proxy indicators facilitate the detection of problematic antibiotic behaviours across and within communities?

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any villager in rural Chiang Rai (Thailand) or Salavan (Lao PDR) who had been sampled to participate in the survey
  • Is willing and able to give informed consent for participation in the study
  • Is aged 18 years and above

Exclusion criteria

  • Respondent is not available or able to participate in interview after two attempts to arrange for appointment

Treatment and study plan

Observational study of behaviour

Behavioral

As a general population survey, our study does not involve a control group. Please note that the investigators do not interview patients; we involve only healthy members of the general public who consider themselves fit to be interviewed.

Primary outcomes

  1. General population and villagelevel data on antibiotic access and use within individuals' healthcare-seeking pathways

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for November 2017 to April 2018

    To improve the understanding of patients' antibiotic-related behaviour to support creative thinking about targeted and unconventional antimicrobial resistance (AMR) interventions in low- and middle-income countries (LMICs).

Secondary outcomes

  1. Indicators of economic, social, and spatial marginalisation

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for November 2017 to April 2018

    To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways.

  2. Access to formal and informal medical treatment

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways.

  3. Access to prescription and over-the-counter medicines including antibiotics

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways.

  4. Degree of technology use during the healthcare seeking process

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways.

  5. Awareness about "rational" antibiotic use

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways.

  6. Typologies of desirable and undesirable healthcare practices with respect to antibiotic use

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To understand whether people's exposure to antibiotic awareness activities entail changed behaviours that diffuse or dissipate within a network of competing healthcare practices.

  7. Social network structures in rural communities

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To understand whether people's exposure to antibiotic awareness activities entail changed behaviours that diffuse or dissipate within a network of competing healthcare practices.

  8. Demand fluctuations for healthcare services over time within rural communities

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To understand whether people's exposure to antibiotic awareness activities entail changed behaviours that diffuse or dissipate within a network of competing healthcare practices.

  9. Proxy indicators that predict problematic antibiotic use in the general population

    Time frame: The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018.

    To identify less data-intensive indicators to detect problematic contexts of antibiotic use

Sponsors and collaborators

Lead sponsor

University of Oxford

Other

Collaborators

  • Economic and Social Research Council, United Kingdom
  • Mae Fah Luang University
  • Mahidol Oxford Tropical Medicine Research Unit

Registry information

Acronym: ESRC

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Aug 7, 2017
Registry last updated
Nov 7, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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