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OpenTrials
Completed

NCT Number: NCT00037050

Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria

This study will treat patients who have a short term central catheter that is thought to be infected with a specific bacteria (gram positive bacteria)

Completed

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Key information

Conditions

Bacterial Infections Bacteremia Bacterial Infections and Mycoses Gram-Positive Bacterial Infections Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

13 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a central indwelling catheter with signs and symptoms of infection

Exclusion criteria

  • Patients with tunneled catheter which cannot be removed.
  • Patients with evidence of endovascular infection including endocarditis.
  • Patients with infection of permanent intravascular devices.
  • Patients who have received more than 1 day of another antibiotic before enrollment.
  • Patients with HIV and low CD4 count.

Treatment and study plan

Linezolid

Drug

Other names: Zyvox

Vancomycin

Drug

Oxacillin

Drug

Dicloxacillin

Drug

Primary outcomes

  1. The empiric treatment of patients with complicated skin and skin structure infections (cSSSI) related to an indwelling catheter;

  2. The empiric treatment of patients with gram-positive catheter-related bloodstream infections.

Secondary outcomes

  1. Clinical efficacy of linezolid compared to vancomycin/oxacillin/dicloxacillin.2.Incidence of late metastatic sequelae associated with S. aureus infections in patients treated with linezolid

Sponsors and collaborators

Lead sponsor

Pfizer

Industry

Registry information

Official study title

Linezolid vs. Vancomycin/Oxacillin/Dicloxacillin in the Treatment of Catheter-Related Gram-Positive Bloodstream Infections

Important dates

Study start
2002
Study completion
2005
First posted
May 15, 2002
Registry last updated
Sep 14, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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