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NCT Number: NCT07435883

Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar

This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars. Thirty-six patients requiring root canal treatment will be included. The study aims to compare bacterial reduction and postoperative pain outcomes after treatment. Results may help improve irrigation protocols and patient comfort during endodontic therapy.

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Key information

Conditions

Pulp Necrosis Dental Pulp Diseases Dental Pulp Necrosis Necrosis Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms Stomatognathic Diseases Tooth Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Oral and Dental Medicine , Future University in Egypt

Cairo, New Cairo, 11835, Egypt

Location contact

hesham salah, MSc

SUB_INVESTIGATOR

reham hassan, PHD

SUB_INVESTIGATOR

sara hosny mostafa adly, BDS

CONTACT

[email protected]

00201009568678

About this study

Root canal disinfection is a critical factor affecting the success of endodontic treatment, especially in teeth with necrotic pulps. Irrigation protocols play an essential role in reducing bacterial load inside the root canal system. The Triton irrigation protocol has been introduced to enhance antimicrobial effectiveness and improve debris removal.

This randomized clinical trial will include 36 patients diagnosed with necrotic mandibular molars indicated for root canal treatment. Participants will receive treatment following the assigned irrigation protocol. Bacterial samples will be collected before and after irrigation to evaluate antibacterial effectiveness. Postoperative pain will be assessed using a standardized pain scale during the follow-up period.

The findings of this study are expected to provide clinical evidence regarding the effectiveness of the Triton irrigation protocol in improving disinfection outcomes and reducing postoperative discomfort

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-45 years with no sex predilection
  • Medically free Patients with no systemic conditions that can affect post operative pain response.
  • Patients should not be taking any pain medications 24 hours before intervention
  • Positive patients' acceptance for participating in the study
  • Patient able to sign informed consent
  • Permanent mandibular molars diagnosis with pulpal necrosis with asymptomatic apical periodontitis.
  • Mandibular molars without any anatomical variations or severe curvatures with mesial roots configuration weine class 3 and a distal root with 2 distal canals

Exclusion criteria

  • Medically compromised patients
  • Patients who have received antibiotic therapy within the last 2 weeks.
  • Pregnant or lactating women.
  • Patients with known allergy to any of the irrigants used.
  • Patients with swelling or acute peri-apical abscess or fistulous tract.
  • Teeth that have:
  • Wide or open apex .
  • Vital pulp tissue .

Treatment and study plan

triton irrigation protocol

Procedure

Root canal irrigation performed using Triton solution according to a standardized endodontic irrigation protocol during root canal treatment.

conventional irrigation group

Procedure

Participants receive conventional root canal irrigation using standard irrigation solutions during chemo-mechanical preparation according to the routine clinical protocol.

Primary outcomes

  1. antibacterial effect

    Time frame: immediately after irrigation procedures

    Reduction in bacterial count will be evaluated by microbiological sampling before and after irrigation.

Secondary outcomes

  1. postoperative pain intensity

    Time frame: 6, 12, 24, and 48 hours after treatment

    Postoperative pain will be assessed using a Visual Analog Scale (VAS) following root canal treatment with different irrigation protocols.

Study contacts

Contact information is provided by the study sponsor or research team.

sara hosny mostafa adly, BDS

CONTACT

[email protected]

00201009568678

Sponsors and collaborators

Lead sponsor

sara hosny mostafa

Other

Registry information

Official study title

Evaluation of Antibacterial Effect and Postoperative Pain Following Irrigation Protocol Using Triton in Necrotic Mandibular Molars. A Randomized Clinical Control Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 27, 2026
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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