Anti-mullerian Hormone Levels in Healthy Females

Anti-mullerian hormone (AMH) is a chemical in the body that is found in the blood that can estimate the ability of a female to have her own children. It is widely used in adult female cancer patients to predict the onset of menopause and/or the inability to have children that can be associated with chemotherapy and/or radiation treatment. Normal blood levels of AMH are better understood in adults than in children and adolescents. The purpose of this study is to have a better understanding of the normal blood levels of AMH in females from 0-18 years of age and how the blood AMH levels correspond to a female's reproductive development. With a better understanding of normal AMH levels in children, we may be able to better assess a girl's risk of not being able to have children if she is a cancer patient, and may be able to offer her and her family options to increase the chances of having her own children.

Inclusion criteria

• Pre- and post-pubertal females
• Ages 0-18 years old
• Tanner Stage I- V
• Undergoing routine outpatient surgical procedure

• Hernia repair (inguinal, umbilical, epigastric)
• Excision of benign mass
• laparoscopic cholecystectomy

Exclusion criteria

• Previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier) or endocrine disorder associated with irregular menstrual cycles (Cushing's disease, poorly-controlled Thyroid disease, hyperprolactinemia, polycystic ovary syndrome, and congenital adrenal hyperplasia) or insulin-dependent diabetes mellitus or autoimmune disorders
• Previous diagnosis of any malignancy or any history of systemic/local chemotherapy, radiation therapy, or stem-cell transplant.
• Previous surgical excision of one ovary or both ovaries
• Pregnant females
• All inpatient surgical patients
• Undergoing non-routine outpatient surgical procedures

• Central venous catheter placement
• Supprelin insertion/removal
• Breast mass excision
• Gastrostomy tube insertion