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NCT Number: NCT06914349

Antecolic Versus Retrocolic Gastrojejunostomy During Whipple's Procedure

Aim: This randomized clinical study aims to compare occurrence of DGE in patients undergoing either antecolic or retrocolic gastrojejunostomy following pancreaticoduodenectomy.

Methods: Participants of this study will be patients undergoing pylorus preserving pancreaticoduodenectomy at the Surgical Department of the University Hospital of Larissa. Patients will be randomized to undergo either an antecolic or a retrocolic gastrojejunostomy and the occurrence of DGE will then be compared between the two groups. Individuals younger than 18 or older than 75 years old, as well as patients who do not consent to participate in this trial, will be excluded.

Expected results: Based on available literature, antecolic gastrojejunostomy may be related with a lower incidence of DGE, without a statistically significant difference between the two methods. We aim to show if one of the two methods of gastrointestinal reconstruction (antecolic versus retrocolic) affects DGE.

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Key information

Conditions

Pancreatic Cancer Resectable Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Neoplasms Neoplasms by Site Pancreas Neoplasms Pancreatic Diseases Pancreatic Neoplasms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Thessaly

Larissa, 41500, Greece

Location status: Recruiting

Location contact

Chrysoula-Christina Kolla

CONTACT

[email protected]

6983075706

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age over 18 years old
  • Elective pancreaticoduodenectomy
  • Signed consent form

Exclusion criteria

  • Age under 18 years old
  • Patients who are participants in other trials that may affect the results of this study
  • Patients who do not consent to participate in the study

Treatment and study plan

Antecolic gastrojejunostomy

Procedure

Gastrojejunostomy in front of the transverse colon

Retrocolic gastrojejunostomy

Procedure

Gastrojejunostomy through the transverse mesocolon

Primary outcomes

  1. Delayed Gastric Emptying

    Time frame: 3 years

    The occurence of delayed gastric emptying will be compared between two groups of patients: those who undergo an antecolic gastrojejunostomy and those who undergo a retrocolic approach.

Study contacts

Contact information is provided by the study sponsor or research team.

Chrysoula C Kolla

CONTACT

[email protected]

+306983075706

Sponsors and collaborators

Lead sponsor

University of Thessaly

Other

Registry information

Official study title

Antecolic Versus Retrocolic Gastrojejunostomy Following Pancreaticoduodenectomy: a Prospective Randomised Study

Important dates

Study start
2025
Primary completion
2028
Study completion
2029
First posted
Apr 6, 2025
Registry last updated
Jun 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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