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Completed

NCT Number: NCT00750347

Antagonistic Interaction CB1-paracetamol

Evaluation of an possible inhibiting effect of Rimonabant on the analgesic effect of Paracetamol in healthy volunteers

Completed

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Key information

Conditions

Pain Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

CHU Clermont-Ferrand, Clermont-Ferrand, France

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About this study

Double Blind, cross-over, randomized and controlled versus placebo, study in healthy volunteers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers
  • between 18 and 40 years old
  • written consent given

Exclusion criteria

  • Rimonabant or paracetamol hypersensibility
  • Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
  • Concomitant medication
  • Chronical diseases

Treatment and study plan

Rimonabant and Paracetamol and placebo

Drug

evaluation of an possible inhibiting effect of rimonabant on the analgesic effect of paracetamol in healthy volunteers

Primary outcomes

  1. Pain's threshold with electrical stimulation (Pain Matcher). Pain's threshold with mechanical stimulation (electronical Von Frey).

    Time frame: during electrical stimulation

Secondary outcomes

  1. Plasmatic concentration of paracetamol or his metabolite with or without Rimonabant

    Time frame: with or without rimonabant

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Registry information

Official study title

Evaluation of the Interaction of Rimonabant (Antagonist of CB1 Receptor) on the Analgesic Effect of Paracetamol in Intravenous Administration

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Sep 10, 2008
Registry last updated
Jan 19, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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