Skip to main content
OpenTrials
Completed

NCT Number: NCT05101538

Anorexia Nervosa and Its Effects on Brain Function, Body Metabolism and Their Interaction

The neuromolecular and metabolic underpinnings of Anorexia Nervosa (AN) are studied using multi-modal molecular (positron emission tomography with two different radioligands) and functional (functional magnetic resonance imaging) neuroimaging in a prospective design. Subjects with AN and normal weight adolescents will be studied with PET and MRI and followed for five years.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Anorexia Nervosa Feeding and Eating Disorders Mental Disorders

Age range

18 year–32 year

Sex eligibility

Female

Study type

Observational

Primary location

Turku PET Centre

Turku, 20521, Finland

About this study

A total of sixty females (30 with AN, 30 healthy controls) are recruited into this prospective study. The subjects will undergo physical examination, body tissue composition measurement, functional and structural MRI of the brain and body, and positron emission tomography (PET) with ligands [18F]-FDG, and [11C]carfentanil. Subjects' weight and physical condition will be followed up for 5 years. The study will start in August 2020 and end in the fall of 2028.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for AN:

  • Female sex
  • Age 18-32 3 years
  • BMI < 17.5 kg/m2
  • Currently fulfilling modified DSM-IV diagnosis of AN with or without amenorrhea, onset age before 25 years
  • Diagnosed less than 2 years ago

For controls:

  • Female sex
  • Age 18-32 3 years
  • BMI 19 20-25 kg/m2
  • No lifetime history of obesity (BMI ≥> 30) or eating disorders

Exclusion criteria

  • Any chronic disease or medication that could affect glucose metabolism or neurotransmission
  • History of psychiatric disorders (excl. AN for the corresponding study group)
  • Smoking of tobacco, taking of snuffs, or use of narcotics
  • Abusive use of alcohol

Treatment and study plan

Primary outcomes

  1. Changes in brain reward system and metabolism in AN patients

    Time frame: 10 years

    AN patients and controls are studied using fMRI and PET imaging and followed 10 years. Reward system function is measured using functional MRI and metabolism using 18F-fluorodeoxy glucose and PETCT imaging

  2. Predictive value of baseline body mass index (BMI), functional brain activation and metabolism in AN

    Time frame: 10 y

    Results from baseline are combined with follow updata

Sponsors and collaborators

Lead sponsor

Turku University Hospital

Other Gov

Registry information

Official study title

Anorexia Nervosa and it's Effects on Brain Function, Body Metabolism and Their Interaction

Acronym: AVAIN-PET

Important dates

Study start
2020
Primary completion
2024
Study completion
2024
First posted
Nov 1, 2021
Registry last updated
Dec 17, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.