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Completed

NCT Number: NCT02661074

Anisakis Blastocystis Cryptosporidium Fish Prevalence

Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health.

Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or symptomatic, resulting in acute gastric, acute intestinal or chronic forms. Allergic manifestations are frequently encountered in gastric forms, but isolated allergic symptoms can occur after ingestion of Anisakidae antigens in raw or cooked fish. Cutaneous contact or Anisakis allergen inhalation have also been reported to induce allergy/anaphylactic reactions or sensitization in the occupational setting in Spain, Italy, Sicilia or South Africa. But no data is available in France.

In this context, the investigators propose to determine and compare the frequency and characteristics of fish allergy in fish workers (fishermen and fish-processing factory workers) and a control population of workers without occupational exposure to fish, in Boulogne-sur-Mer, which is an important fishing port in France, and the first European center for fish processing.

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Key information

Conditions

Anisakis Allergy Anisakiasis Ascaridida Infections Digestive System Diseases Gastrointestinal Diseases Helminthiasis Hypersensitivity Immune System Diseases Infections Intestinal Diseases Intestinal Diseases, Parasitic Nematode Infections Occupational Exposure Parasitic Diseases Secernentea Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre ASTIL, Boulogne-sur-Mer, France

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About this study

162 fishermen, 162 fish-processing factory workers, and 162 control subjects will be consecutively recruited by their occupational doctor during a routine consultation. A standardized questionnaire will be used to collect epidemiological and clinical data on potential allergic manifestation resulting from digestive, cutaneous, or respiratory contact with fish. Domestic and occupational risk factors for fish and Anisakis exposure will also be collected for both allergic and non-allergic patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fisherman followed by the "Service de Santé des Gens de Mer" of Boulogne-sur-Mer, fish-processing factory worker followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, or worker followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, but not working in a fish-processing factory.

Exclusion criteria

  • Pregnant or breast-feeding female
  • Patient with no social insurance
  • Patient unwilling to comply with the protocol
  • Patient unable to understand the study and its objectives
  • Patient under guardianship

Treatment and study plan

Questionnaire

Other

A questionnaire will be completed in order to collect data on:

  • Potential allergic manifestations after fish contact: asthma, allergic rhinitis, conjunctivitis, chronic or acute urticaria, dermatitis/eczema, or severe allergic manifestations (angioedema, bronchospasm, anaphylaxis),
  • Occupational and/or domestic exposure to fish.

Primary outcomes

  1. The prevalence of fish allergy

    Time frame: contact by phone during 30 min at only visit (inclusion)

    Difference in the prevalence of fish allergy between occupationally exposed (fishermen and fish-processing factory workers) and non-exposed subjects.

    the fish allergy is definied by clinical diagnosis based on the presence of clinical manifestations of allergy in contact with the fish ( APC)

Secondary outcomes

  1. Frequencies history of infections Anisakis spp.

    Time frame: contact by phone during 30 min at only visit (inclusion)

    Comparison between occupationally exposed ( E: fishermen and fish-processing factory workers) and non-exposed subjects(NE)

  2. Frequency of fish allergies, history of infections Anisakis spp. (clinical diagnosis)

    Time frame: contact by phone during 30 min at only visit (inclusion)

    comparison between occupationally exposed and non-exposed subjects for previous Anisakidosis.

    Fish exposure will be determined taking into account the handled fish species and the local prevalences of fish parasites.

  3. history of infections Anisakis spp. (clinical diagnosis)

    Time frame: contact by phone during 30 min at only visit (inclusion)

    comparison between occupationally exposed and non-exposed subjects for previous Anisakidosis.

    Fish exposure will be determined taking into account the handled fish species and the local prevalences of fish parasites.

  4. Frequency of risk factors for occupational or domestic exposure to fish:

    Time frame: contact by phone during 30 min at only visit (inclusion)

    comparison subjects (i) allergic or non-allergic Fish (APC + APC-vs) (ii) with or without a history of infection Anisakis spp. (IA + vs IA-).

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Collaborators

  • ANSES
  • Institut Pasteur de Lille
  • Région Nord-Pas de Calais, France

Registry information

Official study title

Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Prevalence of Fish Allergy in Occupational Settings.

Acronym: ABCFish1

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jan 22, 2016
Registry last updated
May 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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