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OpenTrials
Completed

NCT Number: NCT00599105

Angiogenesis in Early Breast Cancer for Prognosis Prediction

This study will investigate the association of angiogenesis in breast cancer measured by magnetic resonance imaging and biomarkers with long-term prognosis of patients.

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Key information

Conditions

Breast Lesions

Age range

18 year–90 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Center for Functional Onco-Imaging, University of California

Irvine, California, 92697, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with a breast mass highly suspicious for malignancy from clinical, mammographic or sonographic examination.
  • The study has been explained to the patient when she is scheduled for surgery.
  • Healthy normal volunteers for imaging protocol optimization.

Exclusion criteria

  • Pregnancy
  • Patients with implanted surgical clips (hemostatic clips) or other ferromagnetic material,
  • Patients engaged in occupations or activities which may cause accidental lodging of ferromagnetic materials, or who may have imbedded metal fragments from military activities,
  • Patients with metallic implants, because they may cause artifacts in diagnostic images due to magnetic field distortion,
  • Patients with implanted prosthetic heart valves,
  • Patients with pacemakers, neuro-stimulation devices,
  • A breast mass with features of benign tumor
  • The patients unwilling to participate in the study or fail to sign the consent form

Treatment and study plan

Magnetic Resonance Imaging

Procedure

MRI contrast agent, 0.1 mmol/kg

Primary outcomes

  1. To investigate whether breast cancer with a higher angiogenesis activity is associated with a unfavorable outcome.

    Time frame: 5 years from completion of enrollment

Secondary outcomes

  1. To investigate whether angiogenesis of breast cancer is associated wit lymph node status

    Time frame: at completion of enrollment

Sponsors and collaborators

Lead sponsor

University of California, Irvine

Other

Registry information

Important dates

Study start
2000
Primary completion
2010
Study completion
2010
First posted
Jan 23, 2008
Registry last updated
Nov 19, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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