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NCT Number: NCT07231614

Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry

Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020).

There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office.

Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office.

Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio.

Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.

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Key information

Conditions

Dental Pain Facial Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Stomatognathic Diseases Tooth Diseases Toothache

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

CESFAM Dr. Jorge Sabat

Valdivia, Los Ríos Region, 5090000, Chile

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques.
  • Patients without systemic diseases (ASA I)
  • Patients with controlled systemic disease (ASA II)
  • Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)
  • Patients with stable periodontal condition, without active infection that could affect the diffusion of the anesthetic.
  • Patients with the ability to understand the procedure and provide informed consent.

Exclusion criteria

  • Patients with uncontrolled systemic diseases ASA III and pregnant patients.
  • Patients requiring trunk techniques (Gow gates, Spix, Carrea)
  • Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants)
  • Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety.
  • Patients with anatomical abnormalities in the orofacial region that interfere with the administration or action of anesthesia.
  • Patients with a history of recent substance abuse.

Treatment and study plan

lidocaine + epinephrine 1:100,000

Drug

Administration of lidocaine as a local anesthetic during dental extraction.

Articaine 4% with epinephrine 1:100,000

Drug

Administration of articaine as a local anesthetic during dental extraction.

Primary outcomes

  1. Number of tubes

    Time frame: immediately after the procedure

    continuous quantitative variable

Secondary outcomes

  1. Pain during dislocation using the Visual Analog Scale (VAS) for pain with a minimum of 0 meaning no pain, and a maximum of 10 meaning the most severe pain ever experienced in life.

    Time frame: After the procedure

    Continuous quantitative variable

Other outcomes

  1. Age

    Time frame: immediately after the procedure

    Continuous quantitative variable.

  2. Sex

    Time frame: Immediately after the procedure.

    Nominal qualitative variable.

Study contacts

Contact information is provided by the study sponsor or research team.

Camila A Henriquez, Student

CONTACT

[email protected]

+56954911248

Natalia A Curín, Student

CONTACT

[email protected]

+56947029930

Sponsors and collaborators

Lead sponsor

Universidad Austral de Chile

Other

Registry information

Official study title

Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry. A Randomized Clinical Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Nov 17, 2025
Registry last updated
Nov 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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