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Active, Not Recruiting

NCT Number: NCT04503148

Anesthesia and Cancer Study: Renal Cell Carcinoma

This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Renal Cell Carcinoma Adenocarcinoma Carcinoma Carcinoma, Renal Cell Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Neoplasms Male Urogenital Diseases Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

About this study

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients scheduled for elective nephrectomy due to renal cell carcinoma

Exclusion criteria

  • Emergency surgery
  • Pregnancy
  • Allergies to anesthetics
  • Palliative surgery
  • Refusal to participate in the study
  • History of diagnosis or surgery for other cancer

Treatment and study plan

Propofol

Drug

Propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

Inhaled General Anesthetics

Drug

Sevoflurane or desflurane for induction and maintenance of anesthesia

Primary outcomes

  1. five year metastasis-free survival

    Time frame: five year after surgery

    five year metastasis-free survival

Secondary outcomes

  1. one year survival

    Time frame: one year after surgery

    survival rate regardless of recurrence

  2. three year survival

    Time frame: three year after surgery

    survival rate regardless of recurrence

  3. one year metastasis-free survival

    Time frame: one years after surgery

    one year metastasis-free survival

  4. three year metastasis-free survival

    Time frame: three years after surgery

    three year metastasis-free survival

  5. five year survival

    Time frame: five year after surgery

    survival rate regardless of recurrence

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

The Influence of Type of Anesthesia on Recurrence of Renal Cell Carcinoma After Nephrectomy: a Prospective Randomized Controlled Study

Important dates

Study start
2020
Primary completion
2022
Study completion
2025
First posted
Aug 7, 2020
Registry last updated
Jul 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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