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NCT Number: NCT04474600

Anesthesia and Acute Kidney Injury After Nephrectomy

This study investigates the influence of type of anesthesia on postoperative renal dysfunction in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics using desflurane.

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Key information

Conditions

Nephrectomy Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, South Korea

About this study

Nephrectomy is considered as a standard therapy for renal cell carcinoma, but it can cause postoperative renal dysfunction, such as acute kidney injury and chronic kidney disease. Therefore, it is imperative to identify modifiable risk factors for postoperative acute kidney injury after nephrectomy in advance. According to a recent retrospective study, total intravenous anesthesia using propofol is significantly associated with lower incidence of acute kidney injury after nephrectomy, compared to the inhalation anesthesia. However, there is no prospective study which investigates the influence of type of anesthesia on postoperative renal function after nephrectomy. Therefore, in the present study, we aimed to investigate the influence of type of anesthesia on acute kidney injury after nephrectomy by performing randomized controlled study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults patients scheduled for elective open nephrectomy

Exclusion criteria

  • Patients diagnosed with acute kidney injury preoperatively
  • Patients who have chronic kidney disease over stage 5 (estimated glomerular filtration rate [eGFR] <15 ml/kg/1.73m2) or have regular hemodialysis preoperatively

Treatment and study plan

Propofol

Drug

The induction and maintenance of anesthesia was performed by total intravenous anesthesia using propofol. In both groups, remifentanil is continuously infused throughout the surgery.

Desflurane

Drug

The induction and maintenance of anesthesia was performed by inhalation anesthesia using desflurane. In both groups, remifentanil is continuously infused throughout the surgery.

Primary outcomes

  1. the incidence of acute kidney injury

    Time frame: during the postoperative seven days

    acute kidney injury (diagnosed by KDIGO criteria)

Secondary outcomes

  1. serum creatinine

    Time frame: postoperative day 1, 3, 14

    postoperative result of serum creatinine

  2. estimated glomerular filtration rate

    Time frame: postoperative day 1, 3, 14

    postoperative result of estimated glomerular filtration rate

  3. biomarker of renal injury

    Time frame: postoperative day 1, 3, 14

    postoperative result of biomarker of renal injury

  4. the incidence of postoperative complications

    Time frame: during the postoperative two weeks

    urine leakage, prolonged ileus, wound infection, retroperitoneal abscess, pneumonia, reoperation, etc.

  5. Length of hospital stay

    Time frame: during the postoperative two weeks

    length of hospital stay

  6. Length of intensive care unit stay

    Time frame: during the postoperative two weeks

    length of intensive care unit stay

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

The Influence of Type of Anesthesia on Postoperative Renal Function After Nephrectomy: a Randomized Controlled Study

Important dates

Study start
2020
Primary completion
2024
Study completion
2024
First posted
Jul 17, 2020
Registry last updated
Dec 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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