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OpenTrials
Completed

NCT Number: NCT00320203

Anecortave Acetate in Patients With Open-angle Glaucoma

The purpose of this study is to evaluate the safety, efficacy, and duration of effect of a single administration of Anecortave Acetate Depot for treatment of elevated intraocular pressure (IOP) in patients with open-angle glaucoma.

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Key information

Conditions

Open-angle Glaucoma Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients 18 years of age or older with open-angle glaucoma.
  • Other protocol-defined inclusion criteria may apply.

Exclusion criteria

  • Patients with open-angle glaucoma with a pseudoexfoliation or pigment dispersion component.
  • Other protocol-defined exclusion criteria may apply.

Treatment and study plan

Anecortave Acetate Sterile Suspension, 6 mg/mL

Drug

Single injection, anterior juxtascleral depot (AJD)

Anecortave Acetate Sterile Suspension, 30 mg/mL

Drug

Single injection, anterior juxtascleral depot (AJD)

Anecortave Acetate Sterile Suspension, 60 mg/mL

Drug

Single injection, anterior juxtascleral depot (AJD)

Anecortave Acetate Vehicle

Other

Single injection, anterior juxtascleral depot (AJD)

Primary outcomes

  1. Mean change in intraocular pressure at 9 am from baseline

    Time frame: Weeks 2 and 6, Months 2, 3, 4, 5, 6, 7.5, 9, 10.5, and 12

Secondary outcomes

  1. Time to treatment failure

    Time frame: At time point

Sponsors and collaborators

Lead sponsor

Alcon Research

Industry

Registry information

Official study title

A Study of the Safety and IOP-Lowering Efficacy of Anecortave Acetate in Patients With Open-Angle Glaucoma

Important dates

Study start
2006
Primary completion
2008
Study completion
2008
First posted
May 3, 2006
Registry last updated
Nov 28, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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