Androgens Level in the Third Trimester of Pregnancy in Patients With Preeclampsia

Methodology:

All women in this study will be subjected to:

• All women are candidates for this study according to inclusion and exclusion criteria.
• History taking with special emphases on last menstrual period to determine the exact Gestational age.
• A reliable date is defined as the occurrence of regular menstrual cycles (28±7 days) in patients who have not taken oral contraceptives during the three months before conception and have no irregular bleeding.
• General and abdominal examination for each patient to determine those patients matching with the inclusion criteria.
• Preeclampsia refers to the new onset of hypertension (systolic blood pressure ≥140 mmHg ,or diastolic blood pressure≥ 90 mmHg ,or both, measured on two occasions > 6 hours apart) and either proteinuria or end organ dysfunction after 20 weeks of gestation in a previously normotensive woman.
• At Ain Shams University Hospitals, the investigator will use ELISA based test system intended for the quantitative measurement of total and free testosterone for patients of both groups.

Inclusion criteria

• Pregnant women (primigravidas) at third trimester i.e. 28-40 weeks.
• Age between 20 and 35 years old.
• Live fetus.
• Having no history of pregestational hypertension.
• Having no history of diseases associated with hormone disorders (thyroid gland disorders, DM, hyperprolactinemia or polycystic ovary syndrome).
• During their pregnancy they did not receive antihypertensive medications.
• Nonsmoker.

Exclusion criteria

• 1- First and second trimester pregnant women. 2- Women younger than 20 years old and older than 35 years old 3- Intrauterine fetal death. 4- History of pregestational hypertension. 5- History of hormonal disorders (thyroid gland disorders and hyperprolactinemia).

6- Smoker. 7- Polycystic ovary syndrome. 8- Signs or symptoms of hyper-androgenism (hirsutism, acne, oily skin, etc.). 9- Diabetes mellitus. 10- Drug use except ordinary supplementation (iron, folic acid).