Anchord Mitral Chordal Repair System - FIH

Inclusion criteria

• Severe symptomatic degenerative mitral regurgitation (grade 3+)
• High surgical risk for open-heart mitral valve repair or replacement
• Suitable anatomy for transcatheter chordal repair as determined by the treating physician
• Ability to undergo required echocardiographic and fluoroscopic imaging
• Ability to provide informed consent

Exclusion criteria

• Active endocarditis or systemic infection
• Severe left ventricular dysfunction (LVEF <30%)
• Significant non-mitral valvular disease requiring intervention
• Severe mitral annular calcification (MAC)
• Presence of intracardiac or femoral venous thrombus or thrombus in the inferior vena cava
• Cerebrovascular events (TIA, CVA) or thromboembolic events within the previous 6 months.
• Renal insufficiency
• Inability to undergo required imaging or access
• Inability to tolerate standard anticoagulation or antithrombotic regimen
• Rheumatic mitral valve disease
• Co-morbid condition limiting life expectancy or study completion
• Pregnancy
• Participation in another clinical trial
• Previous device treatment for MR.