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NCT Number: NCT07006662

Anatomical Landmarks for Chest Wall Perforators Used for Partial Breast Reconstruction

The aim of this 6-month proof-of-concept study is to map out the chest wall perforators in relation to anatomical landmarks for partial breast reconstruction.

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Key information

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

University Hospitals of North Midlands NHS Trust

Stoke-on-Trent, ST4 6QG, United Kingdom

Location contact

Aviva Ogbolosingha

CONTACT

[email protected]

01782 ext. 675380

About this study

Breast conserving surgery is commonly performed in patients with breast cancer. It is important to fill the defect from a breast conserving procedure to achieve good cosmetic outcome. This defect can be filled either by using the adjacent breast tissue or by using perforator flaps; commonly taken from the area posterolateral to the breast or or below the inframammary crease. These perforator flaps can be based on thoracodorsal artery, lateral thoracic artery, lateral intercostal artery or the medial intercostal artery. The identification of these perforators using a hand-held doppler is an important but time-consuming intraoperative step. Surgeons often use the information derived from cadaveric studies when identifying these perforators as there is minimal information on the location of these perforators in relation to anatomical landmarks.

Patients with a BMI of < 25 Kg/m2admitted for elective breast surgery or attending breast outpatients' clinic will be included in the study. Patients will be sent information about this study prior to admission or the clinic appointment with a copy of the consent form. Participants will have a 30-minute assessment using a hand held doppler and perforators will be mapped against soft tissue and bony landmarks. Data will be analysed to identify common anatomical locations for the different chest wall perforators.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing elective breast surgery
  • Age ≥ 18 years
  • Female
  • BMI ≤ 30 kg/m2
  • Willing and able to give fully informed consent,
  • Willing and able to comply with the study procedures

Exclusion criteria

  • Pregnant patients
  • Previous bilateral Breast or axillary surgery
  • Undergoing bilateral oncoplastic procedure or requiring bilateral pre-operative marking
  • Undergoing breast surgery requiring pre-operative marking of some of the landmarks and has had contralateral breast or axillary surgery in the past
  • Surgery planned within 24 hours of screening for eligibility
  • Known history of allergy or contact dermatitis to ultrasound gels

Treatment and study plan

Primary outcomes

  1. Location of vesselse

    Time frame: 6 months

    The location of the AICAP vessels in vertical and horizontal axis using constant bony and soft tissue landmarks. This will be measured by the distance of the perforators from the anatomical landmarks

  2. Location of vessels

    Time frame: 6 months

    The location of the MICAP vessels in vertical and horizontal axis using constant bony and soft tissue landmarks. This will be measured by the distance of the perforators from the anatomical landmarks

  3. Location of vessels

    Time frame: 6 months

    The location of the LTAP vessels in vertical and horizontal axis using constant bony and soft tissue landmarks. This will be measured by the distance of the perforators from the anatomical landmarks

  4. Location of vessels

    Time frame: 6 months

    The location of the LICAP vessels in vertical and horizontal axis using constant bony and soft tissue landmarks. This will be measured by the distance of the perforators from the anatomical landmarks

Secondary outcomes

  1. Variability

    Time frame: 6 months

    The degree of variability in location of the perforators.

Study contacts

Contact information is provided by the study sponsor or research team.

Aviva Ogbolosingha

CONTACT

[email protected]

01782675380

Sponsors and collaborators

Lead sponsor

University Hospitals of North Midlands NHS Trust

Other

Registry information

Official study title

Anatomical Landmarks for Chest Wall Perforators Used for Partial Breast Reconstruction (LaPBrecon)

Acronym: (LaPBrecon)

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 5, 2025
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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