Analyzing the Composition of Tears and Blood for Discovery of Novel Signatures of Aggressive Prostate Cancer

The purpose of this research study is to compare profiles in the blood and tears of patients with and without prostate cancer with the goal of developing a method of separating men with aggressive and non-aggressive disease.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Prostate Cancer Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

35 year–85 year

Sex eligibility

Male

Study type

Observational

Primary location

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male, 35-85 years old
Patients who present for the evaluation of an abnormal exam or test (elevated PSA, abnormal DRE, etc.)
Patients who present for the evaluation of a palpable nodule or induration on prostate exam
Patients who meet the requirements of Group 1, 2, or 3 of the protocol

Exclusion criteria

Patient < 35 or > 85 years of age
Concurrent eye infection or trauma, including active conjunctivitis
Abnormal production of tears (too much or too little)
Any other conditions the PI or staff feels will not fulfill the criteria for study entry or will place the subject in a harmful environment
Atypia on prostate biopsy report

Treatment and study plan

Primary outcomes

Tear Sample

Time frame: 1 day

Tear sample will be taken at the initial clinic visit

Sponsors and collaborators

Lead sponsor

University of Arkansas

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2027
Study completion: 2027
First posted: Jan 23, 2012
Registry last updated: Oct 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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