Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07277348

Analysis of The Outcomes of Therapeutic Photorefractive Keratectomy Combined With Prophylactic Accelerated Cross-Linking (PRK-Plus), for Treatment of Thin Suspicious Cornea

analyze the outcomes of therapeutic photorefractive keratectomy combined with prophylactic accelerated cross-linking (PRK-Plus), for treatment of thin suspicious cornea

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CCT less than 490 microns
  • K mean more than 46 and/or K max more than 47.
  • Astigmatism cylinder >1.5 D.
  • D value of Belin/Ambrósio Module > 1.6
  • inferior- superior asymmetry or bow-tie pattern with skewed radial axes on tangential maps and abnormal changes on (BAD).
  • Asymmetry topography between 2 eyes, even if neither eye"s topographic pattern is in itself decidedly abnormal.
  • Any significant skewed radial axis with or without inferior steepening, or one diopter or more of inferior steepening in some areas but an I-S value of ,1.4,7.
  • young patients with against-the-rule astigmatic patterns.
  • a PTA value 40% if calculated.
  • Abnormal Topographic Patterns
  • K2 reading of corneal back surface less than [-7].
  • D Value of CSTP > 2.5 in Belin/Ambrósio curve
  • We look at values within the central 5 mm circle; the map should be displayed in the BFTE float mode with an estimated area of 8 mm of diameter:
  • Elevation values on the front surface values > +12 μ
  • Elevation values on the back surface values >+15 μ.
  • If there is any isolated island on either front or back surfaces (in the BFS float mode)

Exclusion criteria

  • Eyes diagnosed with KC.
  • CCT less than 450 microns

Treatment and study plan

PRK PLUS

Procedure

therapeutic photorefractive keratectomy combined with prophylactic accelerated cross-linking

Primary outcomes

  1. visual acuity improvement measured by LogMAR system

    Time frame: 1 year

    visual acuity improvement measured by LogMAR system

Sponsors and collaborators

Lead sponsor

Fayoum University

Other

Registry information

Official study title

Analysis of The Outcomes of Therapeutic Photorefractive Keratectomy Combined With Prophylactic Accelerated Cross-Linking (PRK-Plus), for Treatment of Thin Suspicious Cornea: Short-Term Pilot Study

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Dec 11, 2025
Registry last updated
Dec 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.