Analysis of the Eye in Patients With Primary Open-Angle Glaucoma and a Visual Field Defect in One Eye

Two important areas of the eye that need investigation in order to further understanding of glaucoma. First is the retina (part of the eye that converts images from the eye's optical system into electrical impulses sent along the optic nerve to the brain). Newer technology, Spectral Domain Optical Coherence Tomography (SD-OCT), allows us to look at different layers of the retina and carefully measure thickness of each layer. Second area is lamina cribrosa (a portion of the white part of the eye which has nerve fibers passing through it connecting the eye to the brain). If lamina cribrosa is thin, it is possible it may bend easily and disrupt nerve fibers. SD-OCT allows measurement of lamina cribrosa thickness.

Findings will help monitor changes that occur in the eye as a result of glaucoma.

Individuals with primary open-angle glaucoma and unilateral visual field defects were chosen as the main patient population (in addition to normal controls). By approximating each participants baseline anatomy using the fellow, "internal control" eye, investigators will be able to better determine if any changes occur in the macula or the lamina cribrosa as a result of glaucoma.

Inclusion criteria

• Best-corrected visual acuity of 20/40 or better
• No media opacities
• Spherical equivalent refractive errors in a range of -6 to +6 diopters
• Cylinder correction within 3.0 diopters.

Exclusion criteria

• Age < 18 years old
• Visual Acuity < 20/40
• Nuclear sclerosis > +2
• Corneal diseases
• Contact lens use
• History of posterior segment intraocular surgery
• Systemic or ocular diseases that can cause visual field loss.