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NCT Number: NCT07254351

Analysis of the Biomechanical Impact of Lower Limb Length Inequality in PEDiatrics

Lower limb length discrepancy (LLD) is a frequent condition in pediatric orthopedics. Even moderate discrepancies can induce pelvic obliquity and compensatory scoliosis, modifying the distribution of joint loads at the hips and lumbar spine. These biomechanical imbalances are suspected to contribute to early degenerative conditions such as osteoarthritis or chronic low back pain.

The aim of this study is to quantify the biomechanical impact of LLD in children aged 10 to 15 years, using a combination of low dose biplanar EOS imaging (EOS Imaging System) and synchronized ground reaction force (GRF) measurements from integrated force platforms. These data will be used in musculoskeletal models developed in collaboration with the Biomechanics and Impact Mechanics Laboratory (LBMC, Laboratoire de Biomécanique et Mécanique des Chocs), enabling the estimation of hip joint and lumbar intervertebral disc loads.

This is the first pediatric study integrating EOS imaging, force platforms, and personalized musculoskeletal modeling to explore the mechanical consequences of LLD. The findings are expected to improve clinical reasoning and guide early therapeutic strategies.

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Key information

Age range

10 year–15 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospices Civils de Lyon Service d'Orthopédie et de Traumatologie

Bron, 69500, France

Location status: Recruiting

Location contact

Thierry HAUMONT, Pr

CONTACT

[email protected]

04.27.85.57.88 ext. +33

Thierry HAUMONT, Pr

PRINCIPAL_INVESTIGATOR

About this study

Lower limb length discrepancy (LLD) is a frequent condition in pediatric orthopedics. Even moderate discrepancies can induce pelvic obliquity and compensatory scoliosis, modifying the distribution of joint loads at the hips and lumbar spine. These biomechanical imbalances are suspected to contribute to early degenerative conditions such as osteoarthritis or chronic low back pain.

The aim of this study is to quantify the biomechanical impact of LLD in children aged 10 to 15 years, using a combination of low dose biplanar EOS imaging (EOS Imaging System) and synchronized ground reaction force (GRF) measurements from integrated force platforms. These data will be used in musculoskeletal models developed in collaboration with the Biomechanics and Impact Mechanics Laboratory (LBMC, Laboratoire de Biomécanique et Mécanique des Chocs), enabling the estimation of hip joint and lumbar intervertebral disc loads.

A temporary orthopedic compensation (shoe lift) will also be tested to assess its immediate biomechanical effect. Participants will be evaluated at baseline (two EOS acquisitions: with and without compensation) and at 2 years (without compensation).

This is the first pediatric study integrating EOS imaging, force platforms, and personalized musculoskeletal modeling to explore the mechanical consequences of LLD. The findings are expected to improve clinical reasoning and guide early therapeutic strategies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children aged 10-15 years
  • Anatomical LLD > 5 mm, clinically measured
  • EOS imaging indicated by the pediatric orthopedic surgeon in routine care
  • Ability to stand still for 30 seconds without assistance
  • Covered by social security
  • Parental consent and non-opposition obtained

Exclusion criteria

  • - Functional or postural LLD without true anatomical discrepancy
  • History of major pelvic or spinal surgery
  • Severe neurological or orthopedic condition preventing standing (e.g. cerebral palsy, progressive myopathy)
  • Fixed equinus deformity preventing plantar support
  • Major lower limb deformity (severe genu varum/valgum)
  • Contraindication or inability to undergo EOS imaging

Treatment and study plan

EOS Imaging System

Radiation

Low-dose biplanar radiographs of the whole body in standing position (EOS Imaging System). At baseline, two EOS acquisitions will be performed in static standing position : one without compensation (natural position) and one with temporary orthopedic compensation (shoe lift under the shorter limb). At 24 months, one EOS acquisition will be performed without compensation. Each acquisition lasts a few seconds, with radiation exposure 5 to 10 times lower than conventional radiographs.

Force Platform (Bertec®, integrated into EOS cabin)

Device

Ground reaction force (GRF) measurements obtained from a force platform integrated in the EOS cabin. The platform records weight distribution and center of pressure during static standing posture. Measurements are fully synchronized with EOS acquisitions, without additional time or discomfort for participants. At baseline, GRF measurements will be collected in two conditions (with and without orthopedic compensation). At 24 months, GRF measurements will be collected in the non-compensated condition.

Primary outcomes

  1. Asymmetry of Hip Joint Contact Forces (%) in Static Standing

    Time frame: At baseline (Day 0, without compensation)

    Hip joint contact force asymmetry index (%): calculated as AI (%) = 100 × (F_long - F_short) / [(F_long + F_short)/2], where F_long and F_short are side-specific resultant hip joint contact forces (estimated by musculoskeletal modeling from EOS imaging and ground reaction force data). Units: percent (%).Higher values indicate greater asymmetry.

Study contacts

Contact information is provided by the study sponsor or research team.

Dimitri HERRERA-NATIVI

CONTACT

[email protected]

Thierry HAUMONT, MD, PhD

CONTACT

[email protected]

4 27 85 57 88 ext. +33

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Biomechanical Analysis of the Impact of Lower Limb Length Discrepancy on Hip and Lumbar Spine Joints in Children

Acronym: ABILMI-PED

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Nov 28, 2025
Registry last updated
Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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